7 documents found, page 1 of 1
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis An...
Duarte, R; Munsiff, SS; Nahid, P; Saukkonen, JJ; Winston, CA; Abubakar, I; Acuña-Villaorduña, C; Barry, PM; Bastos, ML; Carr, W; Chami, H; Chen, LBackground: On the basis of recent clinical trial data for the treatment of drug-susceptible and drug-resistant tuberculosis (TB), the American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America have updated clinical practice guidelines for TB treatment in children and adults in settings in which mycobacterial cultures, mol...
Toxicological evaluation of lactose and chitosan delivered by inhalation
De Jesus D J Valle; Dinis Oliveira, RJ; Carvalho, F; Bastos, ML; Sanchez S NavarroThese days, inhalation constitutes a promising administration route for many drugs. However, this route exhibits unique limitations, and formulations aimed at pulmonary delivery should include as few as possible additives in order to maintain lung functionality. The purpose of this work was to investigate the safety of lactose and chitosan to the pulmonary tissue when delivered by inhalation. The study was carr...
Sodium salicylate prevents paraquat-induced apoptosis in the rat lung
Dinis Oliveira, RJ; Sousa, C; Remiao, F; Duarte, JA; Ferreira, R; Sanchez S Navarro; Bastos, ML; Carvalho, FThe nonselective contact herbicide, paraquat (PQ), is a strong pneumotoxicant, especially due to its accumulation in the lung through a polyamine uptake system and to its capacity to induce redox cycling, leading to oxidative stress-related damage. In the present study, we aimed to investigate the occurrence of apoptotic events in the lungs of male Wistar rats, 24, 48, and 96 h after PQ exposure (25 mg/kg ip) a...
P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity
Dinis Oliveira, RJ; Remiao, F; Duarte, JA; Ferreira, R; Sanchez S Navarro; Bastos, ML; Carvalho, FThe widespread use of the nonselective contact herbicide paraquat (PQ) has been the cause of thousands of deaths from both accidental and voluntary ingestion. The main target organ for PQ toxicity is the lung. No antidote or effective treatment to decrease PQ accumulation in the lung or to disrupt its toxicity has yet been developed. The present study describes a procedure that leads to a remarkable decrease in...
Kinetics of paraquat in the isolated rat lung: Influence of sodium depletion
Dinis Oliveira, RJ; De Jesus Valle, MJD; Bastos, ML; Carvalho, F; Sanchez S N NavarroParaquat accumulates in the lung through a characteristic polyamine uptake system. It has been previously shown that paraquat uptake can be significantly prevented if extracellular sodium (Na+) is reduced, although the available data correspond to experiments performed using tissue slices or incubated cells. This type of in vitro study fails to give information on the actual behaviour occurring in vivo since th...
Strenuous exercise aggravates MDMA-induced skeletal muscle damage in mice
Duarte, JA; Leao, A; Magalhaes, J; Ascensao, A; Bastos, ML; Amado, FL; Vilarinho, L; Quelhas, D; Appell, HJ; Carvalho, FThe aim of this study was to investigate the influence of ecstasy (MDMA) administration on body temperature and soleus muscle histology in exercised and non-exercised mice. Charles-River mice were distributed into four groups: Control (C), exercise (EX), MDMA treated (M), and M + EX. The treated animals received an i.p. injection (10 mg/kg) of MDMA (saline for C and EX), and the exercise consisted of a 90 min l...
d-Amphetamine-induced hepatoxicity: Possible contribution of catecholamines and...
Carvalho, F; Remiao, F; Soares, ME; Catarino, R; Queiroz, G; Bastos, MLAmphetamines are indirect-acting sympathomimetic drugs widely abused due to their physical and psychostimulating effects. However, the use of these drugs has been associated with numerous reports of hepatotoxicity. While glutathione depletion induced by amphetamines contributes to the exposure of hepatocytes to oxidative damage, other indirect effects attributed to amphetamines may have a role in cell injury. T...