7 documents found, page 1 of 1
Pharmacological NF-κB inhibition decreases cisplatin chemoresistance in muscle-...
Gil da Costa, Rui; Levesque, C; Bianchi-Frias D; Chatterjee, P; Lam, HM; Santos, C; Coleman, IM; Ferreirinha, P; Vilanova, M; Pinto da Cunha, NMost patients with muscle-invasive bladder cancer (MIBC) are not cured with platinum chemotherapy. Up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) is a major mechanism underlying chemoresistance, suggesting that its pharmacological inhibition may increase platinum efficacy. NF-κB signaling was investigated in two patient cohorts. The Cancer Genome Atlas (TCGA) was used to...
Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...
Medeiros, C; Silva, AR; Ferreira, T; Barros, L; Neuparth, MJ; Peixoto, F; Bastos, MMSM; Medeiros, R; Gil da Costa, RM; Pires, MJ; Faustino-Rocha, Ana Infections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic comp...
Assessing the in vivo effects of Aloysia citrodora extract: data from K14-HPV16...
Medeiros-Fonseca, B; Vala, H; Vasconcelos-Nóbrega, C; Faustino-Rocha, Ana I; Medeiros, R; Bastos, MMSM; Gil da Costa, RM; Oliveira, PAIntroduction Aloysia citrodora is used in folk medicine in the preparation of infusions due to its antispasmodic, digestive, sedative, and antipyretic properties. It also has antioxidant and antimicrobial properties.The present study evaluated the in vivo efficacy of aqueous extract (AE) of Aloysia citrodora in K14-HPV16 transgenic mice which HPV16 early genomic region and hence develop multiple-step epithelial...
Is Pteridium aquilinum a partner of cancer? Preliminary data from K14- HPV16 tr...
Medeiros-Fonseca, B; Faustino-Rocha, Ana I; Medeiros, R; Bastos, MMSM; Gil da Costa, RM; Oliveira, PAIs Pteridium aquilinum a partner of cancer? Preliminary data from K14- HPV16 transgenic mice
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-tran...
Almeida, J; Ferreira, T; Santos, S; Pires, MJ; Gil da Costa, RM; Medeiros, R; Bastos, MMSM; Neuparth, MJ; Faustino-Rocha, AI; Abreu, A; Pereira, RAbstract: The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed Grateloupia turuturu has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of G. turuturu against cutaneous pre-malignant lesions in transgenic mi...
Pulegone and Eugenol Oral Supplementation in Laboratory Animals: Results from A...
Ribeiro-Silva, CM; Faustino-Rocha, Ana I.; Gil da Costa, RM; Medeiros, R; Pires, MJ; Gaivão, I; Gama, A; Neuparth, MJ; Barbosa, JV; Peixoto, FEssential oils are natural compounds used by humans for scientific purposes due to their wide range of properties. Eugenol is mostly present in clove oil, while pulegone is the main constituent of pennyroyal oil. To guarantee the safe use of eugenol and pulegone for both humans and animals, this study addressed, for the first time, the effects of these compounds, at low doses (chronic toxicity) and high doses (...
Dietary supplementation with chestnut (Castanea sativa) reduces abdominal adipo...
Rodrigues, P; Ferreira, T; Nascimento-Gonçalves, E; Seixas, F; Costa, RMG; Martins, T; Neuparth, MJ; Pires, MJ; Lanzarin, G; Félix, LM; Venâncio, CThe production of chestnut (Castanea sativa Miller) is mostly concentrated in Europe. Chestnut is recognized by its high content of antioxidants and phytosterols. This work aimed to evaluate the effects of dietary chestnut consumption over physiological variables of FVB/n mice. Eighteen FVB/n male 7-month-old mice were randomly divided into three experimental groups (n = 6): 1 (control group) fed a standard die...