21 documents found, page 1 of 3
Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesi...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana; Silva, Jessica; Silva, Mónica; Pires, Maria João; Neuparth, Maria João; Vala, HelenaAloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, WT, 0...
Exploring the therapeutic potential of Quercus ilex acorn extract in papillomav...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Vasconcelos-Nóbrega, Cármen; Gouvinhas, IrenePapillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have several unexplored ...
Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...
Medeiros, Catarina; Silva, Ana Rita; Ferreira, Tiago; Barros, Lillian; Neuparth, Maria João; Peixoto, Francisco P.; Bastos, Margarida M.S.M.Infections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic com...
Study on the antineoplastic and toxicological effects of pomegranate (Punica gr...
Yu, Manyou; Gouvinhas, Irene; Pires, Maria J.; Neuparth, Maria J.; Costa, Rui M. Gil da; Medeiros, Rui; Bastos, Margarida M.S.M.; Vala, HelenaPunica granatum L. (pomegranate) has been used in functional foods due to its various health benefits. However, the in vivo biological potential of its leaf remains little known. This study has aimed to characterize the antineoplastic and toxicological properties of using pomegranate leaf infusion (PLI) on transgenic mice carrying human papillomavirus (HPV) type 16 oncogenes. Thirty-eight mice were divided into...
Supplementation of an anthocyanin-rich elderberry (Sambucus nigra L.) extract i...
Azevedo, Tiago; Ferreira, Tiago; Ferreira, João Miguel Mendes; Teixeira, Filipa; Ferreira, Diana; Silva-Reis, Rita; Neuparth, Maria JoãoFeatured Application Due to anthocyanins' potential as colorants, this anthocyanin-rich elderberry extract presents a healthier alternative to commercially available colorants and has the potential to be used at industry level. Sambucus nigra L., popularly known as elderberry, is renowned for its amazing therapeutic properties, as well as its uses as a food source, in nutraceuticals, and in traditional medicine...
Characterization of the Human Papillomavirus 16 Oncogenes in K14HPV16 Mice: Sub...
Cochicho, Daniela; Nunes, Alexandra; Gomes, João Paulo; Martins, Luís; Cunha, Mário; Medeiros-Fonseca, Beatriz; Oliveira, PaulaThe study of ()-induced carcinogenesis uses multiple in vivo mouse models, one of which relies on the cytokeratin 14 gene promoter to drive the expression of all HPV early oncogenes. This study aimed to determine the HPV16 variant and sublineage present in the K14HPV16 mouse model. This information can be considered of great importance to further enhance this K14HPV16 model as an essential research tool and opt...
The anti-tumour effect of spearmint (Mentha spicata) in a HPV-16-transgenic mou...
Jesus, T.M.; Silva-Reis, Rita; Pires, Maria João; Lanzarin, Germano; Félix, Luís; Venâncio, Carlos; Costa, Rui Miguel Gil; Bastos, Margarida M.S.M.Infection by Human Papillomavirus (HPV) is the main cause of cervical cancer, highlighting the importance of studying compounds that may reduce viral activity and its lesions/symptoms. The aromatic herb spearmint (Mentha spicata) (MS) has proven anti-tumour properties 1. Thus, this study aimed to evaluate the effects of an hydroethanolic extract obtained from spearmint in HPV16-transgenic (HPV+/-) mice. The ext...
Histological lesions in hpv16-transgenic model: the effect of hidroethanolic ex...
Ferreira, Tiago; Nascimento-Gonçalves, Elisabete; Moutinho, Magda S.S.; Pires, Maria João; Bastos, Margarida M.S.M.; Medeiros, RuiThe K14HPV16 mice is a skin squamous carcinoma model that can be used to test antitumoral properties of several chemical and natural compounds1. Lavandula penduculata (Mill.) Cav., known as lavender, belongs to the Laminaceae family and has been used in traditional medicine as infusions to treat several conditions2. This work aimed to evaluate the effects of the hydroethanolic French lavender extract (FLE) in a...
Toxicological and anti-tumor effects of a linden extract (Tilia platyphyllos Sc...
Patwal, Tiago; Nascimento-Gonçalves, Elisabete; Macedo, Sara; Borges, Inês; Gama, Adelina; Costa, Rui Miguel Gil; Neuparth, Maria JoãoTilia platyphyllos Scop. is a popular broad-leaved tree, native to Central and Southern Europe. Hydroethanolic extracts rich in phenolic compounds obtained from T. platyphyllos Scop. have shown in vitro antioxidant, anti-inflammatory and antitumor properties. The aim of this work was to evaluate the therapeutic properties of a hydroethanolic extract obtained from T. platyphyllos in HPV16-transgenic mice. The an...
Effect of hidroethanolic extract of Lavandula pedunculata (mill.) Cav. On morph...
Nascimento-Gonçalves, Elisabete; Ferreira, Teresa; Moutinho, Magda S.S.; Pires, Maria João; Bastos, Margarida M.S.M.; Medeiros, RuiLavandula penduculata (Mill.) Cav., common English name French lavender, belongs to the Lamiaceae family and has been used as a medicinal plant in infusions for respiratory and digestive systems and as a therapeutic agent with antiseptic action for cleaning wounds [1,2]. The K14HPV16 mice is a skin squamous carcinoma model that can be used to test the antitumoral properties of several chemical and natural produ...