2 documents found, page 1 of 1
Chitosan-based nanoparticles as a dual drug delivery system directed to bone in...
Falcão, J.; Zegre, Miguel; Bastron, S.; Ribeiro, I. A.; Gonçalves, L.; Bettencourt, A.Osteomyelitis treatment is usually described as a challenging issue, mainly because of the necessity of high levels of antimicrobials employed for extended periods, since the infection is characterized by poor blood circulation. Innovative options of targeted and controlled drug delivery systems, presenting sustained antimicrobial release, high concentrations of drugs in the infected areas, low concentrations i...
Chitosan nanoparticles loaded with minocycline targeting osteomyelitis
Zegre, Miguel; Bastron, S.; Ribeiro, I. A.; Caetano, Liliana Aranha; Gonçalves, L.; Bettencourt, A.Effective control of osteomyelitis (bone infection) with reduced toxicity is a current challenge. Targeted and controlled drug delivery systems allow: decreased toxicity, upgraded drug targeting, and improved therapeutic effect. Strategy: a) Innovative chitosan nanoparticulate system: nanoparticles loaded with minocycline (antibacterial), and alternative as a local delivery system; b) Nanoparticles and biofilms...