6 documents found, page 1 of 1
Quality by Design Approach for the Development of Liposome Carrying Ghrelin for...
Barros, Cecília de; Aranha, Norberto; Severino, Patrícia; Souto, Eliana B.; Zielińska, Aleksandra; Lopes, André; Rios, Alessandra; Batain, FernandoThe therapeutic use of peptides has increasingly recognized in the development of new therapies. However, the susceptible enzymatic cleavage is a barrier that needs to overcome. Nose-to-brain delivery associated with liposomes can protect peptides against biodegradation and improve the accessibility to brain targets. The aim was to develop a liposomal formulation as ghrelin carrier. The quality by design (QbD) ...
Nanopesticides in agriculture: benefits and challenge in agricultural productiv...
Chaud, Marco; Souto, Eliana B.; Zielinska, Aleksandra; Severino, Patricia; Batain, Fernando; Oliveira-Junior, Jose; Alves, ThaisNanopesticides are nanostructures with two to three dimensions between 1 to 200 nm, used to carry agrochemical ingredients (AcI). Because of their unique properties, the loading of AcI into nanoparticles offers benefits when compared to free pesticides. However, with the fast development of new engineered nanoparticles for pests control, a new type of environmental waste is being produced. This paper describes ...
Applications of natural, semi-synthetic, and synthetic polymers in cosmetic for...
Alves, Thais F. R.; Morsink, Margreet; Batain, Fernando; Chaud, Marco V.; Almeida, Taline; Fernandes, Dayane A.; da Silva, Classius F.; Souto, Eliana B.Cosmetics composed of synthetic and/or semi-synthetic polymers, associated or not with natural polymers, exhibit a dashing design, with thermal and chemo-sensitive properties. Cosmetic polymers are also used for the preparation of nanoparticles for the delivery of, e.g., fragrances, with the purpose to modify their release profile and also reducing the risk of evaporation. Besides, other cosmetically active nut...
Structural comparison, physicochemical properties, and in vitro release profile...
Souza, Juliana Ferreira de; Pontes, Katiusca da Silva; Alves, Thais Francine Ribeiro; Barros, Cecilia Torqueti de; Amaral, Venancio AlvesLyotropic liquid crystal (LLC) is a nano-biomimetic lipid-based system, which has thermodynamic property that is peculiar to it, and suitable for its structural ordering, which facilitates more intimate contact with the tissues. The LLC as a carrier of curcumin has been much studied, however, this is the first time that hydrotrope method approach has been used in the lamellar system precursor of the LLC nanopar...
Retinal drug delivery: rethinking outcomes for the efficient replication of ret...
Souto, Eliana B.; Sanchez-Lopez, Elena; Campos, Joana R.; da Ana, Raquel; Espina, Marta; Garcia, Maria L.; Severino, Patrícia; Batain, FernandoThe retina is a highly organized structure that is considered to be "an approachable part of the brain." It is attracting the interest of development scientists, as it provides a model neurovascular system. Over the last few years, we have been witnessing significant development in the knowledge of the mechanisms that induce the shape of the retinal vascular system, as well as knowledge of disease processes tha...
Cachexia: pathophysiology and ghrelin liposomes for nose-to-brain delivery
T. de Barros, Cecilia; Rios, Alessandra C.; Alves, Thaís F. R.; Batain, Fernando; Crescencio, Kessi M. M.; Lopes, Laura J.; Zielinska, AleksandraCachexia, a severe multifactorial condition that is underestimated and unrecognized in patients, is characterized by continuous muscle mass loss that leads to progressive functional impairment, while nutritional support cannot completely reverse this clinical condition. There is a strong need for more effective and targeted therapies for cachexia patients. There is a need for drugs that act on cachexia as a dis...