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Conformational Dynamics of the Soluble and Membrane-Bound Forms of Interleukin-...
Luís, João P.; Mata, Ana I.; Simões, Carlos J. V.; Brito, Rui M. M.Interleukin-1 receptor type 1 (IL-1R1) is a key player in inflammation and immune responses. This receptor regulates IL-1 activity in two forms: as a membrane-bound form and as a soluble ectodomain. The details and differences between the conformational dynamics of the membrane-bound and the soluble IL-1R1 ectodomains (ECDs) remain largely elusive. Here, we study and compare the structural dynamics of the solub...
The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflam...
Luís, João P.; Simões, Carlos J. V.; Brito, Rui M. M.The interleukin-1 receptor type 1 (IL-1R1) holds pivotal roles in the immune system, as it is positioned at the "epicenter" of the inflammatory signaling networks. Increased levels of the cytokine IL-1 are a recognized feature of the immune response in the central nervous system (CNS) during injury and disease, i.e., neuroinflammation. Despite IL-1/IL-1R1 signaling within the CNS having been the subject of seve...
An Innovative Sequence-to-Structure-Based Approach to Drug Resistance Interpret...
Alves, Nuno G.; Mata, Ana I.; Luís, João P.; Brito, Rui M. M.; Simões, Carlos J. V.In silico methodologies have opened new avenues of research to understanding and predicting drug resistance, a pressing health issue that keeps rising at alarming pace. Sequence-based interpretation systems are routinely applied in clinical context in an attempt to predict mutation-based drug resistance and thus aid the choice of the most adequate antibiotic and antiviral therapy. An important limitation of app...