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Clinical, histological and molecular profiling of different stages of alcohol-r...
Ventura-Cots, Meritxell; Argemi, Josepmaria; Jones, Patricia D; Lackner, Carolin; El Hag, Mohamed; Abraldes, Juan G; Alvarado, Edilmar; Clemente, AnaObjective: Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking. Design: Two large cohorts of patients were recruited in an international, observational multicentre study: a retrospective co...
Advancing the global public health agenda for NAFLD: a consensus statement
Lazarus, Jeffrey V.; Mark, Henry E.; Anstee, Quentin M.; Arab, Juan Pablo; Batterham, Rachel L.; Castera, Laurent; Cortez-Pinto, Helena; Crespo, JavierNon-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attentio...
Recent advances in alcohol-related liver disease (ALD): summary of a Gut round ...
Avila, Matias A.; Dufour, Jean-François; Gerbes, Alexander L.; Zoulim, Fabien; Bataller, Ramon; Burra, Patrizia; Cortez-Pinto, Helena; Gao, BinAlcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical tri...
Alcohol-related liver disease is rarely detected at early stages compared with ...
Shah, Neil D.; Ventura-Cots, Meritxell; Abraldes, Juan G.; Alboraie, Mohamed; Alfadhli, Ahmad; Argemi, Josepmaria; Badia-Aranda, EsterBackground & aims: Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden of advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages of disease development than patients with hepatitis C virus (HCV) infection or other etiologies. Methods: We performed a cross-sectional study o...