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Regulation of Nuclear Factor κB (NF-κB) Transcriptional Activity via p65 Acetyl...

Pejanovic, Nadja; Hochrainer, Karin; Liu, Tao; Aerne, Birgit L.; Soares, Miguel P.; Anrather, Josef

The NF-κB family member p65 is central to inflammation and immunity. The purpose of this study was to identify and characterize evolutionary conserved genes modulating p65 transcriptional activity. Using an RNAi screening approach, we identified chaperonin containing TCP1 subunit η (CCTη) as a regulator of Drosophila NF-κB proteins, Dorsal and Dorsal-related immunity factor (Dif). CCTη was also found to regulat...

Date: 2012   |   Origin: ARCA - Access to Research and Communication Annals
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