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Case Report: Hyperbilirubinemia in Gilbert Syndrome Attenuates Covid-19-Induced...

Al-kuraishy, HM; Al-Gareeb, AI; Abdullah, SM; Martins, N; Batiha, GES

Gilbert syndrome (GS) is a liver disorder characterized by non-hemolytic unconjugated hyperbilirubinemia. On the other hand, Coronavirus disease 2019 (Covid-19) is a recent viral infectious disease presented as clusters of pneumonia, triggered by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Little is known on the association between SARS-CoV-2 and GS, despite different studies have recently...


Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literatu...

Islam, MT; Quispe, C; Herrera-Bravo, J; Sarkar, C; Sharma, R; Garg, N; Fredes, LI; Martorell, M; Alshehri, MM; Sharifi-Rad, J; Dastan, SD; Calina, D

Dengue remains one of the most serious and widespread mosquito-borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths. Dengue virus infection is especially transmitted through bites of Aedes mosquitos, hugely spread in tropical and subtropical envi...


The Looming Effects of Estrogen in Covid-19: A Rocky Rollout

Al-kuraishy, HM; Al-Gareeb, AI; Faidah, H; Al-Maiahy, TJ; Martins, N; Batiha, GES

In the face of the Covid-19 pandemic, an intensive number of studies have been performed to understand in a deeper way the mechanisms behind better or worse clinical outcomes. Epidemiologically, men subjects are more prone to severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) infections than women, with a similar scenario being also stated to the previous coronavirus diseases, namely, SARS-CoV in...


Management of SARS-CoV-2 Infection: Key Focus in Macrolides Efficacy for COVID-19

Batiha, GES; Zayed, MA; Awad, AA; Shaheen, HM; Mustapha, S; Herrera-Calderon, O; Pagnossa, JP; Algammal, AM; Zahoor, M; Adhikari, A; Pandey, I

Macrolides (e.g., erythromycin, fidaxomicin, clarithromycin, and azithromycin) are a class of bacteriostatic antibiotics commonly employed in medicine against various gram-positive and atypical bacterial species mostly related to respiratory tract infections, besides they possess anti-inflammatory and immunomodulatory effects. Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the severe acu...


COVID-19 and Risk of Acute Ischemic Stroke and Acute Lung Injury in Patients Wi...

Al-kuraishy, HM; Al-Gareeb, AI; Alblihed, M; Martins, N; Batiha, GES

Background: Coronavirus disease 19 (COVID-19) is regarded as an independent risk factor for acute ischemic stroke (AIS) due to the induction of endothelial dysfunction, coagulopathy, cytokine storm, and plaque instability. Method: In this retrospective cohort study, a total of 42 COVID-19 patients with type 2 diabetes mellitus (T2DM) who presented with AIS within 1 week of displaying COVID-19 symptoms were recr...


Factors Behind the Higher COVID-19 Risk in Diabetes: A Critical Review

Magdy Beshbishy, A; Oti, VB; Hussein, DE; Rehan, IF; Adeyemi, OS; Rivero-Perez, N; Zaragoza-Bastida, A; Shah, MA; Abouelezz, K; Hetta, HF; Martins, N

Diabetes mellitus (DM) and coronavirus disease 2019 (COVID-19) are public health issues worldwide, and their comorbidities trigger the progress to severe disease and even death in such patients. Globally, DM has affected an estimated 9.3% adults, and as of April 18, 2021, the World Health Organization (WHO) has confirmed 141,727,940 COVID-19 confirmed cases. The virus is spread via droplets, aerosols, and direc...


Dairy-Derived and Egg White Proteins in Enhancing Immune System Against COVID-19

Batiha, GES; Alqarni, M; Awad, DAB; Algammal, AM; Nyamota, R; Wahed, MII; Shah, MA; Amin, MN; Adetuyi, BO; Hetta, HF; Martins, N; Koirala, N; Ghosh, A

Coronavirus disease (COVID-19) is a global health challenge, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) triggers a plethora of respiratory disturbances and even multiple organs failure that can be fatal. Nutritional intervention is one of the key components toward to a proper management of COVID-19 patients, especially in those requiring medication, and should thus be considered ...


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