37 documents found, page 1 of 4
Evaluation of the cytotoxicity of palladium/phosphine/curcumin complexes agains...
Batista, Alzir Azevedo
In vitro and in vivo studies of fluorescent Half-Sandwich Ru(II)/alizarin compl...
Batista, Alzir Azevedo
Cytotoxic and antiparasitic activities of diphosphine-metal complexes of group ...
Batista, Alzir Azevedo
Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoiso...
Batista, Alzir Azevedo
cis-bis(N-benzoyl-N0 ,N0 -dibenzylthioureido) platinum(II) : synthesis, molecul...
Correa, Rodrigo de Souza; Oliveira, Katia Mara de; Pérez, Hiram; Stevens, Ana María Plutín; Cairo, Raúl Ramos; Mocelo, Raúl; Castellano, Eduardo ErnestoIn this paper, the title compound was synthesized from N-benzoyl-N′,N′-dibenzylthiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X‐ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N′,N′-dibenzylthiourea ligands in a d...
Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colo...
Silva, Suellen Laila Rocha; Baliza, Ingrid R. S.; Dias, Rosane Borges; Sales, Caroline Brandi Schlaepfer; Rocha, Clarissa Araújo GurgelRu(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh3 = triphenylphosphine, Thy = thyminate and bipy = 2,2′-bipyridine) is a potent cytotoxic agent with ability to bind to DNA, inducing caspase-mediated apoptosis in leukemia cells. In this study, we investigated the mechanism underlying the cell death induction by Ru(II)-thymine complex in human colon carcinoma HCT116 cells, as well as its effect in xeno...
Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell prol...
Bomfim, Larissa Mendes; Araujo, Fênix Alexandra de; Dias, Rosane Borges; Sales, Caroline Brandi Schlaepfer; Rocha, Clarissa Araújo GurgelRuthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellular underlying mechanism and in vivo effectiveness of these ruthenium(II) complexes in human acu...
Nucleobase derivatives as building blocks to borm Ru(II)-based complexes with h...
Carvalho, Diogo Émerson Leite de; Oliveira, Katia Mara de; Bomfim, Larissa Mendes; Soares, Milena Botelho Pereira; Bezerra, Daniel PereiraTwo new Ru(II)-based complexes containing 2-thiouracil derivatives, known as 2-thiouracil (2TU) and 6-methyl-2-thiouracil (6m2TU), were synthesized using cis,trans-[RuCl2(PPh3)2(bipy)] as a precursor. The obtained compounds with a general formula trans-[Ru(2TU)(PPh3)2(bipy)]PF6 (1) and trans-[Ru(6m2TU)(PPh3)2(bipy)]PF6 (2) were characterized by analytical techniques such as NMR, UV–vis, and IR spectroscopies, e...
Non-mutagenic Ru(II) complexes: cytotoxicity, topoisomerase IB inhibition, DNA ...
Batista, Alzir Azevedo
A Nanostructures Lipid System to Improve the Oral Bioavailability of Ruthenium(...
Silva, Patricia B. da [UNESP]; Freitas, Eduardo Sinesio de [UNESP]; Solcia, Mariana Cristina [UNESP]; Souza, Paula Carolina de [UNESP]Made available in DSpace on 2019-10-05T04:10:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-06; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Post-Doctoral National Program (PNPD); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Tuberculosis (TB) is an infectious, airborne disease caused by the bacterium Mycobacterium tuberculosis that mainly affects the lungs...