5 documents found, page 1 of 1
In vitro strategies to understand the impact of oral intake on the bioavailabil...
Ribeiro-Oliveira, R; Diniz, C; Ferreira, IMPLVOBioactive peptides from brewer's spent grain (BSG) and brewer's spent yeast (BSY), two by-products of the brewing industry, have great potential as functional food ingredients, dietary supplements or nutraceuticals to reduce the risk of numerous pathological conditions. Nevertheless, the oral administration of these peptides poses great challenges since peptides must undergo gastrointestinal digestion, intestin...
Targeting hematological malignancies with isoxazole derivatives
Majirská, M; Pilátová, MB; Kudlicková, Z; Vojtek, M; Diniz, CCompounds with a heterocyclic isoxazole ring are well known for their diverse biologic activities encompassing antimicrobial, antipsychotic, immunosuppressive, antidiabetic and anticancer effects. Recent studies on hematological malignancies have also shown that some of the isoxazole-derived compounds feature encouraging cancer selectivity, low toxicity to normal cells and ability to overcome cancer drug resist...
Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and m...
Viegas, Olga; Faria, MA; Sousa, JB; Vojtek, M; Goncalves Monteiro, S; Suliburska, J; Diniz, C; Ferreira, IsabelExcessive angiogenesis favours cancer development, allowing cancer invasion. Polyphenols are promising chemopreventive agents, although data gather so far in respect of anthocyanins, namely cyanidin-3-O-glucoside and delphinidin-3-O-glucoside (DG) and respective aglycones are scarce. The capability of these compounds to prevent tumour progression by inhibiting angiogenesis/cell migration/proliferation was studi...
Release inhibitory receptors activation favours the A(2A)-adenosine receptor-me...
Fresco, P; Diniz, C; Queiroz, G; Goncalves, J1 Interactions between A(2A)-adenosine receptors and alpha(2)-, A(1)- and P2- release-inhibitory receptors, on the modulation of noradrenaline release were studied in isolated rat tail artery. Preparations were labelled with [H-3]-noradrenaline, superfused with desipramine-containing medium, and stimulated electrically (100 pulses at 5 Hz or 20 pulses at 50 Hz). 2 Blockade of alpha(2)-autoreceptors with yohimbi...
Facilitation of noradrenaline release by adenosine A(2A) receptors in the epidi...
Queiroz, G; Diniz, C; Goncalves, JThe adenosine-receptor modulation of noradrenaline release was compared in prostatic and epididymal portions of rat vas deferens. In both portions, tritium overflow elicited by electrical stimulation (100 pulses/8 Hz) was reduced by the adenosine A(1) receptor agonist, N-6-cyclopentyladenosine, and enhanced by the nonselective receptor agonist, 5'-N-ethylcarboxamidoadenosine, in the presence of the adenosine A(...