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Evaluation of hematology, general serum biochemistry, bone turnover markers and...
Coelho, Catarina A.; Bordelo, João P.; Camassa, José A.; Barros, Vera A.; Babo, Pedro Miguel Sousa; Gomes, Manuela E.; Reis, R. L.; Azevedo, J. T.Osteoporosis is a metabolic disorder characterized by a loss of bone mass and structure and increasing the risk of fragility fractures, mostly among postmenopausal women. Sheep is a recognized large animal model for osteoporosis research. An experimental group of ewes (3-4 years old) was subjected to ovariectomy (OVX) and weekly glucocorticoid (GC) application for 24 weeks and compared with a sham control group...
Preclinical and translational studies in small ruminants (sheep and goat) as mo...
Dias, Isabel R.; Camassa, José A.; Bordelo, João A.; Babo, Pedro Miguel Sousa; Viegas, Carlos A.; Dourado, N.; Reis, R. L.; Gomes, Manuela E.Purpose of the Review: This review summarizes research on the use of sheep and goats as large animal models of human osteoporosis for preclinical and translational studies. Recent Findings: The most frequent osteoporotic sheep model used is the ovariectomized sheep with 12 months post-operatively or more and the combined treatment of ovariectomized sheep associated to calcium/vitamin D-deficient diet and glucoc...
Bone turnover markers in sheep and goat: a review of the scientific literature
Camassa, José A.; Diogo, Camila C.; Sousa, Cristina P.; Azevedo, Jorge T.; Viegas, Carlos A.; Reis, R. L.; Dourado, N.; Dias, Isabel R.Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also dur...
Evaluation of bone turnover markers and serum minerals variations for predictin...
Sousa, Cristina P.; Lopez-Peña, Mónica; Guzon, Fernando M.; Abreu, Humberto V. de; Luís, Maurino R.; Viegas, Carlos A.; Camassa, José A.Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers ...
Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifesp...
Camassa, José A.; Diogo, Camila C.; Bordelo, João P. A.; Bonelli, Marília de A.; Viegas, Carlos A.; Azevedo, Jorge T.; Dourado, Nuno; Dias, Isabel R.Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as early indicators of prognosis. However, there is a wide range of variability in bone turnover markers due to several factors, such as different ages and metabolic stages, thus it is important to have as much ...
Bone turnover markers for early detection of fracture healing disturbances: A r...
Sousa, Cristina P.; Dias, Isabel R.; Lopez-Peña, Mónica; Camassa, José A.; Lourenço, Paulo J.; Judas, Fernando M.; Gomes, Manuela E.; Reis, Rui L.Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for...
Bone turnover markers for early detection of fracture healing disturbances: A r...
Sousa, Cristina P.; Dias, Isabel R.; Lopez-Peña, Mónica; Camassa, José A.; Lourenço, Paulo J.; Judas, Fernando M.; Gomes, Manuela E.; Reis, R. L.Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for...