Introduction: Neoadjuvant chemotherapy (NAC) has the potential for tumor downstaging and surgery de-escalation. In the axilla, this approach is less established, especially in cN+→ycN0. Targeted axillary dissection is an option, but difficult to concretize. We aim to identify biological factors associated with nodal pathological complete response (pCR) and recognize potential candidates for a more conservative ...
Background/purpose: Locoregional control in breast cancer is a fundamental part of treatment and determinant for survival outcomes. It has been reported that most locoregional recurrence (LRR) events occur in the first 5 years after treatment. However, LRR continue to occur after this timeline, with unclear risk factors and unknown survival impact. Methods: Retrospective singe-centered cohort of patients treate...
INTRODUCTION: In esophageal cancer, surgical resection and its corresponding lymphadenectomy remains the only therapeutic strategy that offers a possibility of cure. Despite the fact that a minimally invasive approach allows for an adequate lymphadenectomy with less associated morbidity, its high technical complexity means that many centers still do not perform it routinely. OBJECTIVE: Systematization...
Introduction: The use of perioperative chemotherapy (CT) in patients with advanced gastric carcinoma increases their overall survival. This therapy may also increase the number of patients with R0 resection. Potential drawbacks of this therapy, besides its toxicity, include increased surgical morbidity. Methods: We retrospectively evaluated the records of patients undergoing gastrectomy with curative intent, fo...
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Devido á sua localização os sarcomas retroperitoneais têm uma apresentação clínica inicial subtil sendo diagnosticados frequentemente quando já atingiram grandes dimensões. A proximidade de estruturas viscerais e vasculares condiciona a possibilidade de se obter margens de ressecção livres de tumor. O papel das terapêuticas complementares (quimioterapia e radioterapia) utilizadas pré operatoriamente ou a título...