15 documents found, page 1 of 2
Significance of Furin Expression in Thyroid Neoplastic Transformation
Azevedo, Maria Teresa; Macedo, Sofia; Canberk, Sule; Cardoso, Luís; Gaspar, Tiago Bordeira; Pestana, Ana; Batista, Rui; Sobrinho-Simões, ManuelAngiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the neoplastic transformation of the thyrocytes has not been th...
Memorado - Da APG a um novo paradigma, a “Ordem dos Geólogos”.
Chaminé, Helder; Batista, Rui; Brilha, José; Duarte, João; Correia, Victor; Esperancinha, Sérgio; Fernandes, Isabel; Guerner Dias, António; Lopes, LuísA Associação Portuguesa de Geólogos (APG) foi fundada em 11 de Novembro de 1976. É uma associação sócio-profissional, sem fins lucrativos, que congrega profissionais da Geologia que se dedicam a domínios diversificados e especializados no âmbito das Ciências da Terra. É membro fundador da Federação Europeia de Geólogos (FEG) e membro da Federação Portuguesa das Associações e Sociedades Científicas (FEPASC). No ...
Biomarkers for Bladder Cancer Diagnosis and Surveillance: A Comprehensive Review
Batista, Rui; Vinagre, Nuno; Meireles, Sara; Vinagre, João; Prazeres, Hugo; Leão, Ricardo; Máximo, Valdemar; Soares, PaulaBladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is a complex disease with several molecular and pathological pathways, thus reflecting different behaviors depending on the clinical staging of the tumor and molecular type. Diagnosis and monitoring of BC is mainly performed by in...
Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benig...
Pestana, Ana; Batista, Rui; Celestino, Ricardo; Canberk, Sule; Sobrinho-Simões, Manuel; Soares, PaulaThe presence of TERT promoter (TERTp) mutations in thyroid cancer have been associated with worse prognosis features, whereas the extent and meaning of the expression and activation of TERT in thyroid tumours is still largely unknown. We analysed frozen samples from a series of benign and malignant thyroid tumours, displaying non-aggressive features and low mutational burden in order to evaluate the presence of...
Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence ...
Batista, Rui; Vinagre, João; Prazeres, Hugo; Sampaio, Cristina; Peralta, Pedro; Conceição, Paulo; Sismeiro, Amílcar; Leão, Ricardo; Gomes, AndreiaBladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70-75% will present disease confined to the mucosa or submucosa, the non-muscle-invasive BC (NMIBC) subtype. Of those, approximately 70% will recur after transurethral resection (TUR). Due to high rate of recurrence, patients are submitted to an i...
NIS expression in thyroid tumors, relation with prognosis clinicopathological a...
Tavares, Catarina; Coelho, Maria João; Eloy, Catarina; Melo, Miguel; da Rocha, Adriana Gaspar; Pestana, Ana; Batista, Rui; Ferreira, Luciana BuenoThyroid cancer therapy is based on surgery followed by radioiodine treatment. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane. We aimed to evaluate if NIS expression in thyroid primary tumors would be helpful in predicting tumor behavior, response to therapy and prognosis. NIS ...
mTOR Pathway in Papillary Thyroid Carcinoma: Different Contributions of mTORC1 ...
Tavares, Catarina; Eloy, Catarina; Melo, Miguel; Gaspar da Rocha, Adriana; Pestana, Ana; Batista, Rui; Bueno Ferreira, Luciana; Rios, ElisabeteThe mammalian target of rapamycin (mTOR) pathway is overactivated in thyroid cancer (TC). We previously demonstrated that phospho-mTOR expression is associated with tumor aggressiveness, therapy resistance, and lower mRNA expression of SLC5A5 in papillary thyroid carcinoma (PTC), while phospho-S6 (mTORC1 effector) expression was associated with less aggressive clinicopathological features. The distinct behavior...
The prognostic impact of TERT promoter mutations in glioblastomas is modified b...
Batista, Rui; Cruvinel-Carloni, Adriana; Vinagre, João; Peixoto, Joana; Catarino, Telmo A.; Campanella, Nathalia Cristina; Menezes, WederHuman hotspot TERT promoter (TERTp) mutations have been reported in a wide range of tumours. Several studies have shown that TERTp mutations are associated with clinicopathological features; in some instances, TERTp mutations were considered as biomarkers of poor prognosis. The rs2853669 SNP, located in the TERT promoter region, was reported to modulate the increased TERT expression levels induced by the recurr...
TERT promoter mutations in pancreatic endocrine tumours are rare and mainly fou...
Vinagre, João; Nabais, Joana; Pinheiro, Jorge; Batista, Rui; Oliveira, Rui Caetano; Gonçalves, António Pedro; Pestana, Ana; Reis, MartaOne of the hallmarks of cancer is its unlimited replicative potential that needs a compensatory mechanism for the consequential telomere erosion. Telomerase promoter (TERTp) mutations were recently reported as a novel mechanism for telomerase re-activation/expression in order to maintain telomere length. Pancreatic endocrine tumors (PETs) were so far recognized to rely mainly on the alternative lengthening of t...
Reflexões sobre Oncologia Pediátrica
Chagas, Mário; Norton, Lucilía; Batista, RuiIntrodução: Este artigo tem por objectivo analisar a situação actual da subespecialidadede Oncologia Pediátrica no nosso País e reflectirsobre o seu futuro, tanto no âmbito assistencial, como noformativo. Destina-se a todos os leitores da Acta Pediátrica Portuguesa e,muito especialmente, aos que têm responsabilidades docentese de planificação dos cuidados de saúde em Pediatria.