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Photoinactivation of bacterial and fungal planktonic/biofilm forms using the co...
Vieira, Cátia; Bartolomeu, Maria; Santos, Adriele R.; Mesquita, Mariana Q.; Gomes, Ana T. P. C.; Neves, Maria Graça P. M. S.; Faustino, Maria Amparo F.Antimicrobial photodynamic therapy (aPDT) is a promising approach against multidrug-resistant microorganisms. In this work, we accessed the photodynamic efficiency of an affordable formulation composed of five cationic porphyrins (FORM) and its combined effect with potassium iodide (KI) on a large spectrum of microorganisms. For this purpose, the aPDT assays were conducted with FORM alone and FORM + KI on plank...
Photodynamic therapy of prostate cancer using porphyrinic formulations
Mesquita, Mariana Q.; Ferreira, Ana Rita; Neves, Maria da Graça P. M. S.; Ribeiro, Daniela; Fardilha, Margarida; Faustino, Maria A. F.Prostate cancer (PCa) is the second most frequent cancer diagnosed in men worldwide. Among the common treatment options, photodynamic therapy (PDT) is being considered a promising local therapy to treat this cancer. Although PDT is an established treatment modality approved for several types of cancer, the low solubility, the reduced tumor selectivity, the absorption in the therapeutic window and the poor clear...
Photodynamic therapy of prostate cancer using porphyrinic formulations
Mesquita, Mariana Q.; Ferreira, Ana Rita; Neves, Maria da Graça P. M. S.; Ribeiro, Daniela; Fardilha, Margarida; Faustino, Maria A. F.Prostate cancer (PCa) is the second most frequent cancer diagnosed in men worldwide. Among the common treatment options, photodynamic therapy (PDT) is being considered a promising local therapy to treat this cancer. Although PDT is an established treatment modality approved for several types of cancer, the low solubility, the reduced tumor selectivity, the absorption in the therapeutic window and the poor clear...
Photodynamic inactivation of methicillin-resistant Staphylococcus aureus on ski...
Braz, Márcia; Salvador, Diana; Gomes, Ana T. P. C.; Mesquita, Mariana Q.; Faustino, M. Amparo F.; Neves, M. Graça P. M. S.; Almeida, AdelaideStaphylococcus aureus is responsible for skin and soft tissue infections. Having in mind increased antibiotic resistance, in this study the efficacy of antimicrobial photodynamic therapy (aPDT) with a porphyrinic formulation (FORM) as photosensitizer (PS) to photoinactivate methicillin-resistant Staphylococcus aureus (MRSA) on skin was evaluated. Potassium iodide (KI) and iodopovidone (PVP-I) were also tested i...
An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy
Mesquita, Mariana Q.; Dias, Cristina J.; Gamelas, Sara; Fardilha, Margarida; Neves, Maria G. P. M. S.; Faustino, Maria Amparo F.Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of s...
Photodynamic inactivation of bioluminescent Escherichia coli by neutral and cat...
Mesquita, Mariana Q.; Menezes, José C. J. M. D. S.; Neves, Maria G. P. M. S.; Tomé, Augusto C.; Cavaleiro, José A. S.; Cunha, Ângela; Almeida, AdelaidePhotodynamic inactivation of bioluminescent Escherichia coli in the presence of cationic chlorin and isobacteriochlorin photosensitizers (PSs) obtained from 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin is described. The spectroscopic data for the neutral and cationic derivatives and their photophysical characterizations, especially fluorescence and singlet oxygen generation capacity are also reported. The r...
Pyrrolidine-fused chlorin photosensitizer immobilized on solid supports for the...
Mesquita, Mariana Q.; Menezes, José C. J. M. D. S.; Pires, Sónia M. G.; Neves, Maria G. P. M. S.; Simões, Mário M. Q.; Tomé, Augusto C.The emergence of resistant microorganism to conventional therapeutics prompted us to search new and better antimicrobial treatment modalities. In this work was envisaged an economically viable and environmental friendly approach to allow successive recovery and removal of the photosensitizer agent after photodynamic treatment. The photodynamic inactivation of bioluminescent Escherichia coli in the presence of a...