4 documents found, page 1 of 1
GUIA PARA PROCESSAMENTO DE DADOS DE CROMATOGRAFIA ACOPLADA A ESPECTROMETRIA DE ...
Borges,Ricardo Moreira; Resende,João Victor Mendes; Moraes,Aldebaran Oliveira de; Pereira,Alana Kelyene; Garrett,Rafael; Bauermeister,AnelizeIn this work, a discussed and step-wise tutorial for LC-MS and GC-MS data processing using the open-access software MZMine2 is presented and discussed. The rationale behind each step was demonstrated to enable the readers to go through their own data and process it accordingly. The main lesson to be learned is that each parameter must be chosen in light of the raw data and no guidelines should suggest a predete...
In vitro metabolism of copalic and kaurenoic acids in rat and human liver micro...
Mauro,Mariana; Silva,Rodrigo Moreira da; Campos,Michel Leandro de; Bauermeister,Anelize; Lopes,Norberto Peporine; Moraes,Natalia Valadares deCopalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to characterize the metabolism of CA and KA in rat and human liver microsomes using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The in vitro assays showed deviations from the Michaelian kinetics in the metabolism of CA and KA. Putative metaboli...
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Paly...
Pinto,Francisco C. L.; Silveira,Edilberto R.; Vasconcelos,Ana Caroline L.; Florêncio,Katharine G. D.; Oliveira,Francisca A. S.; Sahm,Bianca B.A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of an...
Spatial and Temporal Variations in Secondary Metabolites Content of the Brazili...
Gobbo-Neto,Leonardo; Bauermeister,Anelize; Sakamoto,Humberto T.; Gouvea,Dayana R.; Lopes,João Luis C.; Lopes,Norberto P.The genus Lychnophora (Asteraceae) is a medicinal plant traditionally used as anti-inflammatory or analgesic agent. Its biological properties have been widely investigated and correlated with its chemical composition, which could be different between the species and even accordingly to the place and season of collection. In this work, it was investigated the spatial and temporal variations in the secondary meta...