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Clinical correlates and prognostic impact of neurologic disorders in Takotsubo ...

Cammann, Victoria L.; Scheitz, Jan F.; von Rennenberg, Regina; Jäncke, Lutz; Nolte, Christian H.; Szawan, Konrad A.; Stengl, Helena; Würdinger, Michael

Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights rega...


Impact of atrial fibrillation on outcome in Takotsubo syndrome: data from the I...

El‐Battrawy, Ibrahim; Cammann, Victoria L.; Kato, Ken; Szawan, Konrad A.; Di Vece, Davide; Rossi, Aurelio; Wischnewsky, Manfred; Hermes‐Laufer, Julia

Background Atrial fibrillation (AF) is a major risk factor for mortality. The prevalence, clinical correlates, and prognostic impact of AF in Takotsubo syndrome (TTS) have not yet been investigated in a large patient cohort. This study aimed to investigate the prevalence, clinical correlates, and prognostic impact of AF in patients with TTS. Methods and Results Patients with TTS were enrolled from the Internati...


Ethnic comparison in takotsubo syndrome : novel insights from the International...

Imori, Yoichi; Kato, Ken; Cammann, Victoria L.; Szawan, Konrad A.; Wischnewsky, Manfred; Dreiding, Sara; Würdinger, Michael; Schönberger, Maximilian

Background: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enr...


Prognostic impact of acute pulmonary triggers in patients with Takotsubo syndro...

Kato, Ken; Cammann, Victoria L.; Napp, L. Christian; Szawan, Konrad A.; Micek, Jozef; Dreiding, Sara; Levinson, Rena A.; Petkova, Vanya

Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pu...


Patient profiling in heart failure for tailoring medical therapy: a consensus d...

Rosano, Giuseppe M. C.; Moura, Brenda; Metra, Marco; Böhm, Michael; Bauersachs, Johann; Ben Gal, Tuvia; Adamopoulos, Stamatis; Abdelhamid, Magdy

Despite guideline recommendations and available evidence, implementation of treatment in heart failure (HF) is poor. The majority of patients are not prescribed drugs at target doses that have been proven to positively impact morbidity and mortality. Among others, tolerability issues related to low blood pressure, heart rate, impaired renal function or hyperkalaemia are responsible. Chronic kidney disease plays...


Coexistence and outcome of coronary artery disease in Takotsubo syndrome

Templin, Christian; Ghadri, Jelena R; Ruschitzka, Frank; Lüscher, Thomas F; Braunwald, Eugene; Bauersachs, Johann; Bax, Jeroen J; Münzel, Thomas

Aims: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a l...


Intraventricular thrombus formation and embolism in Takotsubo syndrome

Ding, Katharina J.; Cammann, Victoria L.; Szawan, Konrad A.; Stähli, Barbara E.; Wischnewsky, Manfred; Di Vece, Davide; Citro, Rodolfo

Objective: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Addit...


Age-related variations in Takotsubo syndrome

Cammann, Victoria L.; Szawan, Konrad A.; Stähli, Barbara E.; Kato, Ken; Budnik, Monika; Wischnewsky, Manfred; Dreiding, Sara; Levinson, Rena A.

BACKGROUND: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. OBJECTIVES: This study aimed to investigate age-related differences in TTS. METHODS: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: #50 years, middle-a...


2020 ESC Guidelines for the diagnosis and management of atrial fibrillation dev...

Hindricks, Gerhard; Potpara, Tatjana; Dagres, Nikolaos; Arbelo, Elena; Bax, Jeroen J.; Blomström-Lundqvist, Carina; Boriani, Giuseppe; Castella, Manuel

Atrial fibrillation (AF) poses significant burden to patients, physicians, and healthcare systems globally. Substantial research efforts and resources are being directed towards gaining detailed information about the mechanisms underlying AF, its natural course and effective treatments (see also the ESC Textbook of Cardiovascular Medicine: CardioMed) and new evidence is continuously generated and published. The...


Clinical predictors and prognostic impact of recovery of wall motion abnormalit...

Jurisic, Stjepan; Gili, Sebastiano; Cammann, Victoria L.; Kato, Ken; Szawan, Konrad A.; D'Ascenzo, Fabrizio; Jaguszewski, Milosz; Bossone, Eduardo

Background: Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide‐ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results: TTS patients from the International Takotsubo Registry were included in this study. Cut‐off for early LV recovery was determined to be 10 days after t...


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