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Hybrid red blood cell membrane coated porous silicon nanoparticles functionaliz...
Rahikkala, A; Fontana, F; Bauleth-Ramos, T; Correia, A; Kemell, M; Seitsonen, J; Mäkilä, E; Sarmento, B; Salonen, J; Ruokolainen, J; Hirvonen, JErythrocyte-based drug delivery systems have been investigated for their biocompatibility, long circulation time, and capability to transport cargo all around the body, thus presenting enormous potential in medical applications. In this study, we investigated hybrid nanoparticles consisting of nano-sized autologous or allogeneic red blood cell (RBC) membranes encapsulating porous silicon nanoparticles (PSi NPs)...
Hierarchical structured and programmed vehicles deliver drugs locally to inflam...
Li, W; Li, Y; Liu, Z; Kerdsakundee, N; Zhang, M; Zhang, F; Liu, X; Bauleth-Ramos, T; Lian, W; Mäkilä, E; Kemell, M; Ding, Y; Sarmento, BOrally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehi...
Targeted Reinforcement of Macrophage Reprogramming Toward M2 Polarization by IL...
Shahbazi, M; Sedighi, M; Bauleth-Ramos, T; Kant, K; Correia, A; Poursina, N; Sarmento, B; Hirvonen, J; Santos, HAlteration of macrophage polarization from inflammatory (M1) to anti-inflammatory (M2) phenotype can have striking implications for the regeneration of injured tissues, treatment of inflammatory diseases, and relief of autoimmune disorders. Although certain cytokines like interleukin (IL)-4 and IL-13 are capable of inducing M2 macrophage polarization, their therapeutic potential in vivo is suffering from low ef...