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Prognostic value of aI-based quantitative coronary CTA vs human reader-based vi...

Rosendael, Alexander van; Nakanishi, Rine; Bax, Jeroen J.; Pontone, Gianluca; Mushtaq, Saima; Buechel, Ronny R.; Gräni, Christoph; Feuchtner, Gudrun

Background: The severity and extent of whole heart coronary plaque volume and stenosis can be reliably measured by artificial intelligence–guided quantitative coronary computed tomography angiography (AI-QCT). Limited data are available on the potential incremental prognostic value compared with currently recommended qualitative coronary computed tomography angiography (CTA) reads and the coronary artery calciu...


Diagnostic performance of a novel AI-guided coronary computed tomography algori...

Kamila, Putri Annisa; Hojjati, Tara; Nurmohamed, Nick S.; Danad, Ibrahim; Ding, Yipu; Jukema, Ruurt A.; Raijmakers, Pieter G.; Driessen, Roel S.

Background AI-QCTISCHEMIA is a novel artificial intelligence algorithm that predicts myocardial ischemia using quantitative features from coronary computed tomography angiography, providing a noninvasive alternative to functional imaging. However, its diagnostic performance across key demographic subgroups, particularly by sex and age, remains underexplored. We aimed to evaluate the diagnostic performance of AI...


Development and validation of a quantitative coronary CT Angiography model for ...

CREDENCE and PACIFIC-1 Investigators; Nurmohamed, Nick S.; Danad, Ibrahim; Jukema, Ruurt A.; Winter, Ruben W. de; Groot, Robin J. de; Driessen, Roel S.

Background: Noninvasive stress testing is commonly used for detection of coronary ischemia but possesses variable accuracy and may result in excessive health care costs. Objectives: This study aimed to derive and validate an artificial intelligence-guided quantitative coronary computed tomography angiography (AI-QCT) model for the diagnosis of coronary ischemia that integrates atherosclerosis and vascular morph...


Sex and age-specific interactions of coronary atherosclerotic plaque onset and ...

Rosendael, Sophie E. Van; Bax, A. Maxim; Lin, Fay Y.; Achenbach, Stephan; Andreini, Daniele; Budoff, Matthew J.; Cademartiri, Filippo

Aims: The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes. Methods and results: From a large multi-center CCTA registry the Leiden CCTA score ...


Corrigendum to ‘Relation of Gender to Atherosclerotic Plaque Characteristics by...

Jonas, Rebecca; Patel, Toral; Crabtree, Tami R.; Jennings, Robert S.; Heo, Ran; Park, Hyung Bok; Marques, Hugo; Chang, Hyuk Jae; Stuijfzand, Wijnand J.

The authors regret that the original version was published with the wrong ac affiliation. The affiliation has now been corrected. The authors regret any inconvenience caused.


Risk factors based vessel-specific prediction for stages of coronary artery dis...

Park, Hyung Bok; Lee, Jina; Hong, Yongtaek; Byungchang, So; Kim, Wonse; Lee, Byoung K.; Lin, Fay Y.; Hadamitzky, Martin; Kim, Yong Jin; Conte, Edoardo

Background and Hypothesis: The recently introduced Bayesian quantile regression (BQR) machine-learning method enables comprehensive analyzing the relationship among complex clinical variables. We analyzed the relationship between multiple cardiovascular (CV) risk factors and different stages of coronary artery disease (CAD) using the BQR model in a vessel-specific manner. Methods: From the data of 1,463 patient...


Relation of gender to atherosclerotic plaque characteristics by differing angio...

Jonas, Rebecca; Patel, Toral; Crabtree, Tami R.; Jennings, Robert S.; Heo, Ran; Park, Hyung Bok; Marques, Hugo; Chang, Hyuk Jae; Stuijfzand, Wijnand J.

It is unknown whether gender influences the atherosclerotic plaque characteristics (APCs) of lesions of varying angiographic stenosis severity. This study evaluated the imaging data of 303 symptomatic patients from the derivation arm of the CREDENCE (Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia) trial, all of whom underwent coronary computed tomographic angiography and ...


Prevalence and prognostic implications of moderate or severe mitral regurgitati...

Butcher, Steele C.; Prevedello, Francesca; Fortuni, Federico; Kong, William K. F.; Singh, Gurpreet K.; Ng, Arnold C. T.; Perry, Rebecca; Poh, Kian Keong

Background: Significant (moderate or greater) mitral regurgitation (MR) could augment the hemodynamic effects of aortic valvular disease in patients with bicuspid aortic valve (BAV), imposing a greater hemodynamic burden on the left ventricle and atrium, possibly culminating in a faster onset of left ventricular dilation and/or symptoms. The aim of this study was to determine the prevalence and prognostic impli...


Clinical correlates and prognostic impact of neurologic disorders in Takotsubo ...

Cammann, Victoria L.; Scheitz, Jan F.; von Rennenberg, Regina; Jäncke, Lutz; Nolte, Christian H.; Szawan, Konrad A.; Stengl, Helena; Würdinger, Michael

Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights rega...


Impact of atrial fibrillation on outcome in Takotsubo syndrome: data from the I...

El‐Battrawy, Ibrahim; Cammann, Victoria L.; Kato, Ken; Szawan, Konrad A.; Di Vece, Davide; Rossi, Aurelio; Wischnewsky, Manfred; Hermes‐Laufer, Julia

Background Atrial fibrillation (AF) is a major risk factor for mortality. The prevalence, clinical correlates, and prognostic impact of AF in Takotsubo syndrome (TTS) have not yet been investigated in a large patient cohort. This study aimed to investigate the prevalence, clinical correlates, and prognostic impact of AF in patients with TTS. Methods and Results Patients with TTS were enrolled from the Internati...


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