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Statins are amongst the most prescribed drugs worldwide and they are generally safe. A rare but potentially serious adverse effect of statins’ therapy has been described– anti-3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (anti-HMGCR) immune-mediated necrotizing myopathy (IMNM) – that can occur years after the drug has beenstarted. We conducted a literature review after illustratinga typical case of anti-HMG...
Disseminated intravascular coagulation (DIC) is an acquired clinical and laboratory syndrome that results in excessive and unregulated activation of the coagulation cascade. Although thrombotic manifestations are common, clinically significant cerebral arterial ischemia is rarely reported. We report the case of an 80-year-old man admitted for multifocal stroke, altered coagulation tests, and worsening renal fun...
Percussion hemoglobinuria is an underdiagnosed entity, rarely reported in the scientific literature. It is a syndrome that involves intravascular hemolysis with consequent hemoglobinuria in musicians of manual percussion instruments when they are subjected to repetitive trauma to the hands for prolonged periods of time.Acute kidney injury associated with percussion hemoglobinuria is usually multifactorial, rela...
Quality of care for older surgical in-patients, often suffering from pre-existing co-morbidity, requires hospital organiza- tion fostering the cooperation of multi-disciplinary teams. Co-management programmes have proved to be the most adequate for this purpose. However, the costs involved in this approach warrant careful patient selection. Ascertaining surgical risk in individual patients is a pre-re- quisite ...
The autors describe a patient with a 5 month history of astenia, anorexia and weigth loss. Three months after the begining of the disease disphagia for solid food appearede as well as dispnœa. The investigation led to the diagnosis of alcohol related chronic pancreatitis with infected mediastinal pseudo-cyst, pancreatic fistula, pancreatic pleural effusion and probable splenic artery thrombosis.; Os autores des...