3 documents found, page 1 of 1
Metabolism-Targeted Therapy in NSCLC - A New Theranostics Inhalation Approach U...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Glucagon and Glucose Availability Influence Metabolic Heterogeneity and Maligna...
Ferreira, Bárbara; Lemos, Isabel; Mendes, Cindy; Chumbinho, Beatriz; silva, fernanda; Pereira, Daniela; Vigia, Emanuel; G Goncalves, LuisFunding Information: The institutions are funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020), and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). This study was supported by a Terr...
MCT1 a peon in metabolic adaptation and a crucial target in lung cancer
Mendes, CindyAbstract Lung cancer remains a global health challenge, with late-stage diagnosis and treatment resistance contributing to its devastating impact. In the past two decades, lung cancer therapy has witnessed notable progress, transitioning from cytotoxic treatments to more tolerable and highly effective targeted regimens, particularly tailored to specific molecular subtypes. Despite these advancements, challenges...