13 documents found, page 1 of 2

Synthesis of cardanol-based 1,2,3-triazoles as potential green agents against n...

Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol...

Made available in DSpace on 2018-11-29T06:20:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01. Added 1 bitstream(s) on 2019-10-09T18:25:56Z : No. of bitstreams: 1 S0103-50532018000300639.pdf: 347454 bytes, checksum: 0e8bf43c43cd9b732cb0cc1b7921b7cd (MD5); FUNDECT (PRONEM); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Supe...

Synthesis and enzymatic resolution of racemic 2,3-epoxy propyl esters obtained ...

(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerizat...

(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone (PHT) is a known cytotoxic compound belonging to the phenstatin family. However, the exact mechanism of action of PHT-induced cell death remains to be determined. The aim of this study was to investigate the mechanisms underlying PHT-induced cytotoxicity. We found that PHT displayed potent cytotoxicity in different tumor cell lines, showing IC50 values in the n...

Electrochemical and theoretical evaluation of the interaction between dna and a...

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:48:50Z No. of bitstreams: 1 S0100-40422010000600014.pdf: 733506 bytes, checksum: f69b94d86f8654488c7afabfdfe546a4 (MD5); Made available in DSpace on 2013-08-22T18:48:50Z (GMT). No. of bitstreams: 1 S0100-40422010000600014.pdf: 733506 bytes, checksum: f69b94d86f8654488c7afabfdfe546a4 (MD5) Previous issue date: 2010-01-01; Made availabl...

Total synthesis and allelopathic activity of cytosporones A-C

A busca por herbicidas eficientes e ambientalmente corretos tem sido foco de numerosos estudos sobre a síntese de compostos isolados de fontes naturais. Citosporonas, as quais são lipídeos fenólicos isolados de fungos, apresentam notáveis propriedades biológicas. Este artigo relata a preparação das citosporonas A, B e C, através de uma rota sintética curta e com excelentes rendimentos. Os compostos sintetizados...

Synthesis of resorcinolic lipids bearing structural similarities to cytosporone A

Inspired by the structure and biological activities of resorcinolic lipids and, particularly cytosporone A- a potent inhibitor of plantule germination and growth, we have performed the synthesis of the analogs 3-heptyl-3-hydroxy-5,7-dimethoxy-2-benzofuran-1(3H)-one (1) and 3-heptyl-3-hydroxy-4,6-dimethoxy-2-benzofuran-1(3H)-one (2). The intermediates and products were submitted to allelopathic test using Lactuc...

Chemical modifications of a natural xanthone and antimicrobial activity against...

A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized deriv...

Transformações químicas do (+)-10β,14-diol-allo-aromadendrano, isolado de dugue...

The sesquiterpene (+)-allo-aromadendrane-10β-14-diol 1 was the lead compound to the preparation of several derivatives in order to test their biological activity against A. salina, C. sphaerospermum, E. coli and S. aureus. In this way the monoalcohols (+)-viridiflorol 4, 9 and 11 were synthesized from 1 together with the acetal 6, the ketal 7, and the ketone 8. The oxirane 3 and nitrile 5 were also prepared usi...

Electrochemical and theoretical evaluation of the interaction between dna and a...

The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the...