4 documents found, page 1 of 1
Profiling of urinary extracellular vesicle protein signatures from patients wit...
Bernardino, R; Carvalho, AS; Hall, MJ; Alves, L; Leão, R; Sayyid, R; Pereira, H; Beck, HC; Campos-Pinheiro, L; Henrique, R; Fleshner, N; Matthiesen, RPrognostic tests and treatment approaches for optimized clinical care of prostatic neoplasms are an unmet need. Prostate cancer (PCa) and derived extracellular vesicles (EVs) proteome changes occur during initiation and progression of the disease. PCa tissue proteome has been previously characterized, but screening of tissue samples constitutes an invasive procedure. Consequently, we focused this study on liqui...
Assessment of a Large-Scale Unbiased Malignant Pleural Effusion Proteomics Stud...
Zahedi, S; Carvalho, AS; Ejtehadifar, M; Beck, HC; Rei, N; Luís, A; Borralho, P; Bugalho, A; Matthiesen, RBackground: Pleural effusion (PE) is common in advanced-stage lung cancer patients and is related to poor prognosis. Identification of cancer cells is the standard method for the diagnosis of a malignant PE (MPE). However, it only has moderate sensitivity. Thus, more sensitive diagnostic tools are urgently needed. Methods: The present study aimed to discover potential protein targets to distinguish malignant pl...
Extracellular Vesicle Proteome in Prostate Cancer: A Comparative Analysis of Ma...
Bernardino, RM; Leão, R; Henrique, R; Pinheiro, LC; Kumar, P; Suravajhala, P; Beck, HC; Carvalho, AS; Matthiesen, RMolecular diagnostics based on discovery research holds the promise of improving screening methods for prostate cancer (PCa). Furthermore, the congregated information prompts the question whether the urinary extracellular vesicles (uEV) proteome has been thoroughly explored, especially at the proteome level. In fact, most extracellular vesicles (EV) based biomarker studies have mainly targeted plasma or serum. ...
Transcriptome Reprogramming of CD11b(+) Bone Marrow Cells by Pancreatic Cancer ...
Maia, J; Otake, AH; Poças, J; Carvalho, AS; Beck, HC; Magalhães, A; Matthiesen, R; Strano Moraes, MC; Costa-Silva, BPancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b+ bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b+ BM c...