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Host and microbiota interactions are critical for development of murine Crohn’s...
Roulis, M; Bongers, G; Armaka, M; Salviano, T; He, Z; Singh, A; Seidler, U; Becker, C; Demengeot, J; Furtado, G C; Lira, S A; Kollias, GDeregulation of host-microbiota interactions in the gut is a pivotal characteristic of Crohn's disease. It remains unclear, however, whether commensals and/or the dysbiotic microbiota associated with pathology in humans are causally involved in Crohn's pathogenesis. Here, we show that Crohn's-like ileitis in Tnf(ΔARE/+) mice is microbiota-dependent. Germ-free Tnf(ΔARE/+) mice are disease-free and the microbiota...
Date: 2016
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Origin: ARCA - Access to Research and Communication Annals