13 documents found, page 1 of 2
Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in...
Mendes-Pinheiro, Bárbara; Anjo, Sandra I.; Manadas, Bruno; Da Silva, Jorge D.; Marote, Ana; Behie, Leo A.; Teixeira, Fábio G.; Salgado, António J.Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or neuroprotective treatment for PD is available. Recent studies have brought attention to the variety of bioactive molecules produced by mesenchymal stem cells (MSCs), g...
Extremely low frequency magnetic field induces human neuronal differentiation t...
Özgün, Alp; Marote, Ana Maria Franco Aveiro; Behie, Leo A.; Salgado, A.; Garipcan, BoraMagnetic fields with different frequency and intensity parameters exhibit a wide range of effects on different biological models. Extremely low frequency magnetic field (ELF MF) exposure is known to augment or even initiate neuronal differentiation in several in vitro and in vivo models. This effect holds potential for clinical translation into treatment of neurodegenerative conditions such as autism, Parkinson...
Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in...
Pinheiro, Bárbara Filipa Mendes; Anjo, Sandra I.; Manadas, Bruno; da Silva, Jorge D.; Marote, Ana Maria Franco Aveiro; Behie, Leo A.; Teixeira, Fábio G.Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or neuroprotective treatment for PD is available. Recent studies have brought attention to the variety of bioactive molecules produced by mesenchymal stem cells (MSCs), g...
Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and ...
Mendes-Pinheiro, Bárbara; Teixeira, Fábio G.; Anjo, Sandra I.; Manadas, Bruno; Behie, Leo A.; Salgado, António J.Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results from the death of dopamine (DA) neurons. Over recent years, differentiated or undifferentiated neural stem cells (NSCs) transplantation has been widely used as a means of cell replacement therapy. However, compelling evidence has brought attention to the array of bioactive molecules produced by stem cells, defined as secr...
Exploiting the impact of the secretome of MSCs isolated from different tissue s...
Silva, Rita Catarina Assunção Ribeiro; Pinheiro, Bárbara Filipa Mendes; Patrício, Patrícia; Behie, Leo A.; Teixeira, Fábio Gabriel RodriguesCell transplantation using Mesenchymal stem cell (MSC) secretome have recently been presented as a possible free-based therapy for CNS related disorders. MSC secretome is rich in several bio-factors that act synergically towards the repair of damaged tissues, thus making it an ideal candidate for regenerative applications. Great effort is currently being made to map the molecules that compose the MSC secretome....
Influence of passage number on the impact of the secretome of adipose tissue st...
Serra, Sofia Cravino; Costa, João C.; Silva, Rita Catarina Assunção Ribeiro; Teixeira, Fábio Gabriel Rodrigues; Silva, Nuno André MartinsMesenchymal stem cells (MSCs), and within them adipose tissue derived stem cells (ASCs), have been shown to have therapeutic effects on central nervous system (CNS) cell populations. Such effects have been mostly attributed to soluble factors, as well as vesicles, present in their secretome. Yet, little is known about the impact that MSC passaging might have in the secretion therapeutic profile. Our aim was to ...
Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and ...
Pinheiro, Bárbara Filipa Mendes; Teixeira, Fábio Gabriel Rodrigues; Anjo, Sandra I.; Manadas, Bruno; Behie, Leo A.; Salgado, A. J.Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results from the death of dopamine (DA) neurons. Over recent years, differentiated or undifferentiated neural stem cells (NSCs) transplantation has been widely used as a means of cell replacement therapy. However, compelling evidence has brought attention to the array of bioactive molecules produced by stem cells, defined as secr...
Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and ...
Teixeira, Fábio G.; Carvalho, Miguel M.; Panchalingam, Krishna M.; Rodrigues, Ana J.; Mendes-Pinheiro, Bárbara; Anjo, Sandra I.; Manadas, BrunoResearch in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been proposed as a possible therapeutic tool for the treatment of Parkinson's disease (PD). Indeed, it has been shown that the MSC secretome increases neurogenesis and cell survival, and has numerous neuroprotective actions under different conditions. Addition...
Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and ...
Teixeira, Fábio Gabriel Rodrigues; Carvalho, Miguel M.; Panchalingam, K. M.; Rodrigues, Ana João; Pinheiro, Bárbara Filipa Mendes; Anjo, SandraResearch in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been proposed as a possible therapeutic tool for the treatment of Parkinson's disease (PD). Indeed, it has been shown that the MSC secretome increases neurogenesis and cell survival, and has numerous neuroprotective actions under different conditions. Addition...
Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bio...
Teixeira, Fábio G.; Panchalingam, Krishna M.; Assunção-Silva, Rita; Serra, Sofia C.; Mendes-Pinheiro, Bárbara; Patrício, Patrícia; Jung, SunghoonIn recent years it has been shown that the therapeutic benefits of human mesenchymal stem/stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly attributed to their secretome. The implementation of computer-controlled suspension bioreactors has shown to be a viable route for the expansion of these cells to large numbers. As hMSCs actively respond to their culture environment, there is the hypothes...