15 documents found, page 1 of 2

Sustained macrophage reprogramming is required for CD8+ T cell–dependent long-t...

Tumor-associated macrophages (TAM) exhibit a dual role in tumor progression and antitumor immunity. However, understanding the functional states and molecular mechanisms of antitumor TAMs remains a challenge. Herein, we show that intratumoral administration of a combination of agonists against TLR3 and CD40 [hereafter termed myeloid cell treatment (MCT)] reprogrammed TAMs in situ to adopt a protective antitumor...

Estudo dos Fatores Explicativos do tipo de Opinião Emitida pelo Auditor nos Mun...

Objetivo: O objetivo deste estudo foi estudar os fatores explicativos do tipo de opinião, emitida pelo auditor, nos municípios portugueses de média dimensão, no período de 2016 a 2018. Referencial teórico: A literatura tem relatado que a opinião emitida no relatório de auditoria é afetada por diversos fatores (Ferreira & Morais, 2019). No entanto, ainda há muito o que investigar e aprender sobre quais são estes...

Review of Piezoelectrical Materials Potentially Useful for Peripheral Nerve Repair

It has increasingly been recognized that electrical currents play a pivotal role in cell migration and tissue repair, in a process named “galvanotaxis”. In this review, we summarize the current evidence supporting the potential benefits of electric stimulation (ES) in the physiology of peripheral nerve repair (PNR). Moreover, we discuss the potential of piezoelectric materials in this context. The use of these ...

The immune microenvironment in multiple myeloma : friend or foe?

Multiple myeloma (MM) is one of the most prevalent hematological cancers worldwide, characterized by the clonal expansion of neoplastic plasma cells in the bone marrow (BM). A combination of factors is implicated in disease progression, including BM immune microenvironment changes. Increasing evidence suggests that the disruption of immunological processes responsible for myeloma control ultimately leads to the...

Statistical methods for the study of extracellular vesicles content and their p...

Árvores Monumentais: análise comparativa da legislação nacional e europeia rela...

Atendendo à inexistência de legislação comunitária europeia, relativa à proteção das árvores monumentais, procurou-se conhecer a realidade legislativa, em vinte e três países do continente europeu. Assim, procedeu-se à análise comparativa da legislação sobre as árvores monumentais e dos critérios de classificação deste arvoredo, com base nas figuras de proteção legal existentes. Os países foram selecionados com...

A importância da afetividade na educação para valores

O presente relatório foi realizado no âmbito da Unidade Curricular de Prática de Ensino Supervisionada do Mestrado de Qualificação para a docência em Educação Pré-Escolar. Esta investigação tem como principal objetivo compreender o papel dos afetos na educação para valores, tendo em consideração a experiência pedagógica dos Educadores de Infância. A educação para valores deve fazer parte do dia a dia de qualque...

In vitro blood flow and cell-free layer in hyperbolic microchannels: visualizat...

Red blood cells (RBCs) in microchannels has tendency to undergo axial migration due to the parabolic velocity profile, which results in a high shear stress around wall that forces the RBC to move towards the centre induced by the tank treading motion of the RBC membrane. As a result there is a formation of a cell free layer (CFL) with extremely low concentration of cells. Based on this phenomenon, several works...

Blood flow visualization and measurements in microfluidic devices fabricated by...

The most common and used technique to produce microfluidic devices for biomedical applications is the soft-lithography. However, this is a high cost and time-consuming technique. Recently, manufacturers were able to produce milling tools smaller than 100 μm and consequently have promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing cell separation. In this wor...

Low cost microfluidic device for partial cell separation: micromilling approach

Several studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers have been able to produce milling tools smaller than 100 microns,...