2 documents found, page 1 of 1
Chassis optimization as a cornerstone for the application of synthetic biology ...
Beites, T; Mendes, MVThe increased number of bacterial genome sequencing projects has generated over the last years a large reservoir of genomic information. In silico analysis of this genomic data has renewed the interest in bacterial bioprospecting for bioactive compounds by unveiling novel biosynthetic gene clusters of unknown or uncharacterized metabolites. However, only a small fraction of those metabolites is produced under l...
Streptomyces natalensis programmed cell death and morphological differentiation...
Beites, T; Oliveira, P; Rioseras, B; Pires, SD; Oliveira, R; Tamagnini, P; Moradas-Ferreira, P; Manteca, Á; Mendes, MVStreptomyces are aerobic Gram-positive bacteria characterized by a complex life cycle that includes hyphae differentiation and spore formation. Morphological differentiation is triggered by stressful conditions and takes place in a pro-oxidant environment, which sets the basis for an involvement of the oxidative stress response in this cellular process. Characterization of the phenotypic traits of Streptomycesn...