Agradecimentos: This research was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq, Brasil (grant 446647/2014-4; fellowships 162598/2013-0 and 167908/2013-8) and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP (fellowships 2011/06191-7 and 2012/07206-0). Author contributions: MJS and FDCLA conceived and designed the experiments; TDSR, AT, KRAB, and VGS performed the ex...
Universidade Federal de Minas Gerais; This work presents an in vitro investigation of protein restriction in the metabolism of albendazole (ABZ). The study was conducted with microsomal fractions obtained from Wistar rats using a High Performance Multidimensional Liquid Chromatography method which was developed and fully validated for the determination of the ABZ metabolites albendazole sulphoxide (ABZ-SO), alb...
Universidade Federal de Minas Gerais; This work presents the development and validation of a sensitive and enantioselective multidimensional high performance liquid chromatography (HPLC) method for determination of albendazole metabolites: albendazole sulphoxide, chiral compound, albendazole sulphone and albendazole 2-aminesulphone in bovine plasma. The compounds, (±)- albendazole sulphoxide, albendazole sulpho...