3 documents found, page 1 of 1
Fructose metabolism and lipogenesis fluxes in mice models of diet-induced non-a...
Belew, Getachew DebasTese de Doutoramento em Biologia Experimental e Biomedicina apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra.; Non-alcoholic fatty liver disease, characterised as an abnormal accumulation of triglyceride in hepatocytes, is one of the most prevalent chronic liver disease globally in current times. It is associated with many metabolic disorders related to overfeeding including ...
Loss of postprandial insulin clearance control by Insulin-degrading enzyme driv...
Borges, Diego O; Patarrão, Rita S; Ribeiro, Rogério T.; de Oliveira, Rita Machado; Duarte, Nádia; Belew, Getachew Debas; Martins, MadalenaSystemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player in IC control yet the role of hepatic IDE in glucose and lipid homeostasis remains unexplored. We hypothesized that IDE governs postprandial IC and hepatic IDE dysfunction am...
Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as t...
Jarak, Ivana; Barosa, Cristina; Martins, Fátima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, João; Viegas, IvanThe positional analysis of hepatic glycogen enrichment from deuterated water (2 H2 O) by 2 H NMR has been applied previously to resolve the contributions of glucose and fructose to glycogen synthesis in rodents fed a high sucrose diet. To further validate this method, this analysis was applied to mice fed with synthetic diets whose carbohydrate components consisted solely of either glucose or fructose.; The aut...