5 documents found, page 1 of 1
Pharmaceutical vehicles for vaginal and rectal administration of anti-hiv micro...
Mesquita, L; Galante, J; Nunes, R; Sarmento, B; Neves, JPrevention strategies play a key role in the fight against HIV/AIDS. Vaginal and rectal microbicides hold great promise in tackling sexual transmission of HIV-1, but effective and safe products are yet to be approved and made available to those in need. While most efforts have been placed in finding and testing suitable active drug candidates to be used in microbicide development, the last decade also saw consi...
Asthma and rhinitis have different genetic profiles for IL13, IL17A and GSTP1 p...
Resende, EP; Todo-Bom, A; Loureiro, C; Mota-Pinto, A; Oliveiros, B; Mesquita, L; Silva, HCBACKGROUND: Asthma and rhinitis have a complex etiology, depending on multiple genetic and environmental risk factors. An increasing number of susceptibility genes are currently being identified, but the majority of reported associations have not been consistently replicated across populations of different genetic backgrounds. PURPOSE: To evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A...
Doseamento das granzimas A e B na sarcoidose pulmonar (estudo experimental)
Dourado, M; Bento, J; Mesquita, L; Marques, A; Vale-Pereira, S; Ribeiro, AB; Mota-Pinto, ASarcoidosis is a systemic disease of unknown aetiology, morphologically characterized by well-formed epithelioid granulomas, which show little or no central necrosis. These may be present in any organ or tissue. The lung is the most frequently and prominently involved target. The granuloma is often very sharply demarcated from the adjacent tissue and is surrounded by a mantle of lymphocytes, which mediate lysis...
CD26/DPPIV and response to hepatitis B vaccination
Dourado, M; Alves, V; Mesquita, L; Ramos, I; Pinto, AM; Rosa, MSThe prevention of hepatitis B is important, since it is responsible for significant morbidity and mortality around the world. Unfortunately, hepatitis B vaccine does not always induce protective immunity. The lack of immune response to vaccine (non-responders) can depend on individual characteristics. The objective of this study was to correlate the CD26/DPPIV cellular expression and DPPIV serum activity with H...
Envolvimento pulmonar subclínico em sarcoidose cutânea
Robalo-Cordeiro, C; Gonçalo, Margarida; Lima, MA; Mesquita, L; Teixeira, L; Santos-Rosa, M; Azevedo-Bernarda, R; Poiares-Baptista, A; Robalo-Codeiro, AJ