3 documents found, page 1 of 1
Framework for clinical trials in cerebral small vessel disease (FINESSE)
Markus, Hugh S.; van Der Flier, Wiesje M.; Smith, Eric E.; Bath, Philip; Biessels, Geert Jan; Briceno, Emily; Brodtman, Amy; Chabriat, HuguesImportance: Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease mechanisms in SVD differ from other stroke etiologies; therefore, treatments need to be evaluated in cohorts in which SVD has been well characterized. Furthermore, SV...
Prevalence of cerebral amyloid pathology in persons without dementia
Jansen, Willemijn J.; Ossenkoppele, Rik; Knol, Dirk L.; Tijms, Betty M.; Scheltens, Philip; Verhey, Frans R. J.; Visser, Pieter Jelle; Aalten, PaulineImportance: Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies. Objective: To use individual participant data meta-analysis to estimate the prevalence of amyloid pathology as meas...
Apathy and suicide-related ideation 3 months after stroke: a cross-sectional study
Tang, Wai Kwong; Caeiro, Lara; Lau, Chieh Grace; Liang, Huajun; Mok, Vincent; Ungvari, Gabor S.; Wong, Ka SingBackground: Both apathy and suicide are common in poststroke patients. However, the association between poststroke apathy and suicide-related ideation (SI) in Chinese stroke patients is not clear and poorly understood. The aim of this study was to examine the association between apathy and SI in stroke. Methods: A cross-sectional study was conducted to investigate the association in 518 stroke survivors from Ac...