The classical BCR-ABL-negative Myeloproliferative Neoplasms (MPN) are a group of heterogeneous haematological diseases characterized by constitutive JAK-STAT pathway activation. Targeted therapy with Ruxolitinib, a JAK1/2-specific inhibitor, achieves symptomatic improvement but does not eliminate the neoplastic clone. Similar effects are seen with histone deacetylase inhibitors (HDACi), albeit with poorer toler...
Oomycetes from the genus Phytophthora are fungus-like plant pathogens that are devastating for agriculture and natural ecosystems. They are able to secrete a glucanase inhibitor protein (GIP) that inhibits the activity of endoglucanases (EGases) involved in defense responses against infection. One of the most widely distributed and aggressive Phytophthora species, with more than 1,000 host plants is P. cinnamom...
Oomycetes from the genus Phytophthora are fungus-like plant pathogens that are devastating for agriculture and natural ecosystems. Due to their particular physiological characteristics, no efficient treatments against diseases caused by these microorganisms are presently available. To develop such treatments, it appears essential to dissect the molecular mechanisms that determine the interaction between Phytoph...
Oomycetes from the genus Phytophthora are fungos-likeplant pathogens that are devastating fr agriculture and natural ecosystems. Due to their partucular physiological characteristics, no eficiente tratmentts, it against diseases caused by these microorganisms are presently available. To develop such treatments, it appears essential to dissect the molecular mechanisms that determine the interaction between Phyto...
Trichodorma spp. covers a group of fungi extremely common in soils of all climatic areas. These fungi arc efficient enzyme producers, with industrial applications, or in nature, involved in the degradation of the coli wall of the phytopathogens as well as in the degradation of other fungi, organic matter and nutrients secreted by roots.
The genus Trichoderma is cosmopolitan in soils, wood decomposition and plant material. Species of Trichoderma are often dominant components of the soil microflora in various habitats. This is due to different metabolic capacity of the Trichoderma species and its aggressive competitiveness in nature. The genus Trichoderma are frequently used in biological control because of its antagonist ability of phytopathoge...
Species of the genus Phytophthora secrete glucanase inhibitor proteins (GIPs) to inhibit the activity of enzymes involved in plant defense responses, including during plant infection process of Castanea sativa Mill by Phytophthora cinnamomi. GIPs show structural homology to the chymotrypsin class of serine proteases (SP) but lack proteolytic activity due to the absence of an intact catalytic triad and, thus, be...
Wild plant essential oil effects on the growth control of Phytophthora cinnamomi and Castanea sativa M. João Sousa1, Fátima Martins1, Hélio Belo1, Altino Choupina1, 2 and Anabela Martins1 1Instituto Politécnico de Bragança, Escola Superior Agrária, Campus de Santa Apolónia, Apartado 1172, 5301-854 Bragança, Portugal 2CIMO- Centro de Investigação de Montanha, Campus de Santa Apolónia, Apartado 1172, 5301-854 Bra...
The oomycetes form a phylogenetically distinct group of eukaryotic microorganisms that includes some of the most notorious pathogens of plants. Among these, members of the genus Phytophthora cause enormous economic losses on crop species as well as environmental damage in natural ecosystems. Phytophthora cinnamomi is the most widely distributed Phytophthora species, with nearly 1000 host species.