4 documents found, page 1 of 1
miRNAs in Heart Development and Disease
Lozano-Velasco, Estefania; Inácio, José Manuel; Sousa, Inês; Guimarães, Ana Rita; Franco, Diego; Moura, Gabriela; Belo, José AntónioCardiovascular diseases (CVD) are a group of disorders that affect the heart and blood vessels. They include conditions such as myocardial infarction, coronary artery disease, heart failure, arrhythmia, and congenital heart defects. CVDs are the leading cause of death worldwide. Therefore, new medical interventions that aim to prevent, treat, or manage CVDs are of prime importance. MicroRNAs (miRNAs) are small ...
Myocardial RNA sequencing reveals new potential therapeutic targets in heart fa...
Inácio, José M.; Cristo, Fernando; Pinheiro, Miguel; Vasques-Nóvoa, Francisco; Saraiva, Francisca; Nunes, Mafalda M.; Rosas, Graça; Reis, AndreiaHeart failure with preserved ejection fraction (HFpEF) represents a global health challenge, with limited therapies proven to enhance patient outcomes. This makes the elucidation of disease mechanisms and the identification of novel potential therapeutic targets a priority. Here, we performed RNA sequencing on ventricular myocardial biopsies from patients with HFpEF, prospecting to discover distinctive transcri...
Transthoracic echocardiography reference values in juvenile and adult 129/Sv mice
Vinhas, Maurícia; Araújo, Ana Carolina; Ribeiro, Sónia; Rosário, Luís Brás; Belo, José AntónioBackground: In the recent years, the use of Doppler-echocardiography has become a standard non-invasive technique in the analysis of cardiac malformations in genetically modified mice. Therefore, normal values have to be established for the most commonly used inbred strains in whose genetic background those mutations are generated. Here we provide reference values for transthoracic echocardiography measurements...
Rotinas de vida e a frequência cardíaca: Estudo sobre a actividade física nos t...
Faustino, António; Serrano, João; Belo, José António; Moreira, Mafalda; Martins, Maria de Jesus; Machado, SusanaO presente estudo tem por objectivo relacionar as actividades diárias de uma criança do sexo masculino de 10 anos, do meio urbano com a oscilação da frequência cardíaca registada nessas mesmas actividades. A recolha dos dados foi efectuada através de um registo diário das actividades e do uso de um monitor de frequência cardíaca, durante uma semana tipo no período pós-escolar. Os dados obtidos foram inicialment...