17 documents found, page 1 of 2
Bilirubin is independently associated with oxidized LDL levels in young obese p...
Nascimento, H.; Alves, A.; Coimbra, S.; Catarino, C.; Gomes, D.; Bronze-da-Rocha, E.; Costa, E.; Rocha-Pereira, P.; Aires, L.; Mota, J.; Mansilha, H.BACKGROUND: Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation, in young obese individuals. FINDINGS: 125 obese patients (13.4 years; 53.6% females) were studied. TB, l...
Comparison between CDC and WHO BMI z-score and their relation with metabolic ri...
Nascimento, H; Catarino, C; Mendonça, D; Oliveira, P; Alves, A; Medeiros, A; Rocha-Pereira, P; Rêgo, C; Mansilha, H; Aires, L.; Mota, J.Growth-curves are an important tool for evaluating the anthropometric development in pediatrics. The different growth-curves available are based in different populations, what leads to different cut-offs. Pediatric obesity tracks into adulthood and is associated with increased cardiovascular risk. The accurate assessment of a child nutritional status using growth-curves can indicate individuals that are either ...
Protective effect of C. sativa leaf extract against UV mediated-DNA damage in a...
Almeida, Isabel F.; Pinto, A.S.; Monteiro, C.; Monteiro, H.; Belo, L.; Fernandes, J.; Bento, A.R.; Duarte, T.L.; Garrido, J.; Bahia, Maria FernandaToxic effects of ultraviolet (UV) radiation on skin include protein and lipid oxidation, and DNA damage. The latter is known to play a major role in photocarcinogenesis and photoaging. Many plant extracts and natural compounds are emerging as photoprotective agents. Castanea sativa leaf extract is able to scavenge several reactive species that have been associated to UV-induced oxidative stress. The aim of this...
Therapeutic strategies for pediatric obesity and their effect in cardiovascular...
Nascimento, H.; Quintanilha, A.; Santos-Silva, A.; Belo, L.Pediatric obesity is an important public health problem nowadays. Portugal is no exception, being one third of children and adolescent either overweight or obese. The behavioral approach is the basilar stone of obese treatment nowadays. It focuses in change lifestyle, substituting unhealthy habits by new, healthier, ones.A great number of strategies have been studied to try to respond to this growing problem, w...
Iron as the key modulator of hepcidin expression in erythroid antibody-mediated...
Fernandes, J. C.; Garrido, P.; Ribeiro, S.; Rocha-Pereira, P.; Bronze-da-Rocha, E.; Belo, L.; Costa, E.; Reis, F.; Santos-Silva, A.Erythroid hypoplasia (EH) is a rare complication associated with recombinant human erythropoietin (rHuEPO) therapies, due to development of anti-rHuEPO antibodies; however, the underlying mechanisms remain poorly clarified. Our aim was to manage a rat model of antibody-mediated EH induced by rHuEPO and study the impact on iron metabolism and erythropoiesis. Wistar rats treated during 9 weeks with a high rHuEPO ...
Potential cardiovascular risk protection of bilirubin in end-stage renal diseas...
Sameiro-Faria, M.; Kohlova, M.; Ribeiro, S.; Rocha-Pereira, P.; Teixeira, L.; Nascimento, H.; Reis, F.; Miranda, V.; Bronze-da-Rocha, E.We evaluated the potential cardiovascular risk protection of bilirubin in hemodialysis (HD) patients. An enlarged set of studies were evaluated in 191 HD patients, including hematological study, lipid profile, iron metabolism, nutritional, inflammatory markers, and dialysis adequacy. The TA duplication screening in the UDP-glucuronosyltransferase 1 A1 (UGT1A1) promoter region was also performed. The UGT1A1 geno...
Body fat percentage is a major determinant of total bilirubin independently of ...
Belo, L.; Nascimento, H.; Kohlova, M.; Bronze-da-Rocha, E.; Fernandes, J.; Costa, E.; Catarino, C.; Aires, L.; Mansilha, H.; Rocha-Pereira, P.OBJECTIVES: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in you...
Aging is associated with impaired renal function, INF-gamma induced inflammatio...
Costa, E.; Fernandes, J.; Ribeiro, S.; Garrido, P.; Rocha-Pereira, P.; Coimbra, S.; Catarino, C.; Reis, F.; Belo, L.; Bronze-da-Rocha, E.; Vala, HelenaOur aim was to contribute to a better understanding of the pathophysiology of anemia in elderly, by studying how aging affects renal function, ironmetabolism, erythropoiesis and the inflammatory response, using an experimental animal model. The study was performed in male Wistar, a group of young rats with 2 months age and an old one with 18 months age. Old rats presented a significant higher urea, creatinine, ...
Cardiac antiapoptotic and proproliferative effect of recombinant human erythrop...
Teixeira, M.; Rodrigues-Santos, P.; Garrido, P.; Costa, E.; Parada, B.; Sereno, J.; Alves, R.; Belo, L.; Teixeira, F.; Santos-Silva, A.; Reis, F.Objective: Recombinant human erythropoietin (rhEPO) therapy under circumstances of moderate chronic renal failure (CRF), with yet lower kidney and heart lesion, may have a protective cardiac effect beyond the correction of anemia, whose mechanism deserves better elucidation, namely by clarifying the impact on gene expression profile of markers of apoptosis, inflammation, proliferation, angiogenesis, and lesion/...
46 – Mild reductions in BMI Z-score through lifestyle modifications seem to imp...
Nascimento, H.; Rocha, S.; Fernandes, J.; Costa, E.; Rego, C.; Mansilha, H. F.; Rocha-Pereira, P.; Quintanilha, A.; Santos-Silva, A.; Belo, L.