2 documents found, page 1 of 1
Insight into pathogenomics and phylogeography of hypervirulent and highly-letha...
Mokrousov, Igor; Vyazovaya, Anna; Shitikov, Egor; Badleeva, Maria; Belopolskaya, Olesya; Bespiatykh, Dmitry; Gerasimova, Alena; Perdigão, JoãoBackground The Mycobacterium tuberculosis Beijing genotype is globally spread lineage with important medical properties that however vary among its subtypes. M. tuberculosis Beijing 14717-15-cluster was recently discovered as both multidrug-resistant, hypervirulent, and highly-lethal strain circulating in the Far Eastern region of Russia. Here, we aimed to analyze its pathogenomic features and phylogeographic p...
Molecular Insight into Mycobacterium tuberculosis Resistance to Nitrofuranyl Am...
Mokrousov, Igor; Slavchev, Ivaylo; Solovieva, Natalia; Dogonadze, Marine; Vyazovaya, Anna; Valcheva, Violeta; Masharsky, Aleksey; Belopolskaya, OlesyaWe performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain Mycobacterium tuberculosis H37Rv. The most active compound 11 was used for in vitro selection of spontaneous resistant mutants. The same mutations in si...