7 documents found, page 1 of 1
High cholesterol diet exacerbates blood-brain barrier disruption in LDLr–/– mic...
Oliveira, Jade de; Engel, Daiane F.; Paula, Gabriela C. de; Santos, Danubia B. dos; Lopes, Jadna B.; Farina, Marcelo; Moreira, Eduardo L. G.Background: Evidence has revealed an association between familial hypercholesterolemia and cognitive impairment. In this regard, a connection between cognitive deficits and hippocampal blood-brain barrier (BBB) breakdown was found in low-density lipoprotein receptor knockout mice (LDLr–/–), a mouse model of familial hypercholesterolemia. Objective: Herein we investigated the impact of a hypercholesterolemic die...
Metabolic activity in cryopreserved and grafted ovarian tissue using high-resol...
Rodrigues, Aline de Queiroz; Picolo, Victor Luna; Goulart, Jair Trapé; Silva, Isabella M. G.; Ribeiro, Rayane B.; Aguiar, Beatriz A.Cryopreservation of ovarian tissue followed by transplantation represents a strategy to restore ovarian function and fertility. Stress from cryopreservation-thawing processes can lead to alterations and/or damage to mitochondrial structure and functionality. High resolution respirometry and histological analysis were used to evaluate the effect of cryopreservation and transplantation on ovarian tissue. Four dif...
Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) ...
Melo, Heloísa Antoniella Braz de; Nascimento, Gabriel Pasquarelli do; Corrêa, Rafael; Almeida, Raquel das Neves; Santos, Igor de OliveiraZika virus (ZIKV) has a strong tropism for the nervous system and has been related to post-infection neurological syndromes. Once neuronal cells are infected, the virus is capable of modulating cell metabolism, leading to neurotoxicity and cellular death. The negative efect of ZIKV in neuron cells has been characterized. However, the description of molecules capable of reversing these cytotoxic efects is still ...
Diphenyl diselenide protects neuronal cells against oxidative stress and mitoch...
Quispe, Ruth Liliám; Jaramillo, Michael Lorenz; Galant, Leticia Selinger; Engel, Daiane; Dafre, Alcir Luiz; Rocha, João Batista Teixeira daOxidative stress and mitochondrial dysfunction are critical events in neurodegenerative diseases; therefore, molecules that increase cellular antioxidant defenses represent a future pharmacologic strategy to counteract such conditions. The aim of this study was to investigate the potential protective effect of (PhSe)2 on mouse hippocampal cell line (HT22) exposed to tert-BuOOH (in vitro model of oxidative stres...
Disseleneto de difenila: um organocalcogênio com baixa toxicidade em não roedor...
Bem, Andreza Fabro deCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; Atherosclerosis is a chronic inflammatory condition associated with an overproduction of oxidant species. Since low density lipoprotein (LDL) oxidation plays a key role in the pathogenesis of atherosclerosis, antioxidants that can inhibit this oxidative process might be useful in preventing atherosclerosis-related pathological conditions, such as card...
Avaliação da expressão do citocromo P4501A1 hepático e das defesas antioxidante...
Bem, Andreza Fabro deDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde; O benzonidazol (BZN) é um derivado nitroimidazol dotado de uma notável atividade tripanocídica e vem sendo utilizado no Brasil como o único fármaco empregado no tratamento da doença de Chagas. Possivelmente, o mecanismo de ação do BZN seja via produção de espécies reativas de oxigênio (ERO) geradas através do processo ...
Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LD...
Bem, Andreza Fabro de; Farina, Marcelo; Portella, Rafael de Lima; Nogueira, Cristina Wayne; Dinis, Teresa C. P.; Laranjinha, João A. N.Oxidative modification of low-density lipoprotein (LDL) represents an important factor in atherogenesis. In the present study, we have investigated the antioxidant capability of diphenyl diselenide (PhSe)2, a simple organoseleno compound, against copper (Cu2+) and peroxyl radical-induced human LDL oxidation in vitro. In initial studies using human serum, (PhSe)2 caused a dose-dependent inhibition of Cu2+-induce...