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Initial Results of the International Efforts in Screening New Agents against Ca...

Poester, Vanice Rodrigues; Munhoz, Lívia Silveira; Benelli, Jéssica Louise; Melo, Aryse Martins; Al-Hatmi, Abdullah M.S.; Larwood, David J.

Background: Candida auris is an emergent fungal pathogen and a global concern, mostly due to its resistance to many currently available antifungal drugs. Objective: Thus, in response to this challenge, we evaluated the in vitro activity of potential new drugs, diphenyl diselenide (PhSe)2 and nikkomycin Z (nikZ), alone and in association with currently available antifungals (azoles, echinocandins, and polyenes) ...


Anti-Aspergillus fumigatus IgG in patients with bronchiectasis and its relation...

Rodrigues Trápaga, Mariana; Rodrigues Poester, Vanice; Sanchotene, Karine Ortiz; Martins Melo, Aryse; Benelli, Jéssica Louise; Basso, Rossana Patricia

Aspergillosis is a mycosis, most commonly afecting the airways. This mycosis can worsen the clinical condition of patients with concurrent lung diseases. We assayed for the presence of serum anti-A. fumigatus IgG in bronchiectasis patients from a tertiary hospital in south Brazil and evaluated the relationship with clinical outcome. Thirty-one patients with bronchiec tasis, without cystic fbrosis, were included...


Aspergilose pulmonar crónica: os desafios para o diagnóstico e aplicabilidade d...

Trápaga, Mariana Rodrigues; Martins Melo, Aryse; Poester, Vanice Rodrigues; Basso, Rossana Patricia; Sabino, Raquel; Verissimo, Cristina

Introdução: Estima‐se que anualmente 3 milhões de pessoas em todo o mundo desenvolvam aspergilose pulmonar crônica (CPA), no entanto, seu diagnóstico é desafiador. Objetivo: Relatar o caso de um paciente com repetidos isolamentos de A. fumigatus em amostras respiratórias desde 2013, e diagnóstico de CPA confirmado somente em 2019. Metodologia: Homem, 73 anos, diagnóstico de HIV em 2000 (desde 2010 supressão vir...


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