4 documents found, page 1 of 1
3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents fo...
Silva , V.; Benfeito, S.; Lima , C.; Chavarria, D.; Gonçalves, T.; Costa , I.; Remião , F.; Borges, F.; Silva , R.Background: Parkinson’s Disease (PD) is a multifactorial, complex and progressive neurodegenerative disease, characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta [1,2]. Several pathophysiological mechanisms are involved in PD, namely Lewy bodies formation, mitochondrial dysfunction, neuroinflammation, oxidative stress and iron accumulation within the brain [3]. Iron tr...
The versatility of membrane-water partitioning in pharmacokinetic modelling
Fernandes, Eduarda; Soares, Telma; Almeida, A.; Benfeito, S.; Lopes, Carla Martins; Sarmento, Bruno; Borges, Fernanda; Real Oliveira, Maria Elisabete
Drug biophysical profiling using lipid-based colloidal nanosystems and human se...
Fernandes, Eduarda Barbosa; Real Oliveira, M. Elisabete C.D.; Benfeito, S.; Cagide, Fernando; Borges, F.; Lúcio, M.[Excerpt] Why? In the drug discovery process it should be considered that in physiological environment there will be reciprocal interactions between drugs and biological interfaces, such as cell membranes or plasma proteins, and from those interactions different pharmacokinetic profiles can be achieved.[...]
Drug biophysical profiling using lipid-based colloidal nanosystems and human se...
Fernandes, Eduarda Barbosa; Real Oliveira, M. Elisabete C.D.; Benfeito, S.; Cagide, Fernando; Borges, F.; Lúcio, M.The development of new drugs is a highly complex and expensive process, so it is crucial that less promising compounds are rejected early in the discovery phase before progressing to more expensive phases. This scenario impels researchers to refine and speed up the drug discovery process and to seek tools to support decisions related to modifications of the drug chemical structure to improve drugs’ properties a...