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Cohort Profile: the Etude Epidémiologique sur les Petits Ages Gestationnels-2 (...

Lorthe, E; Benhammou, V; Marchand-Martin, L; Pierrat, V; Lebeaux, C; Durox, M; Goffinet, F; Kaminski, M; Ancel, PY; EPIPAGE-2 Study Group

Medical practices and the organization of care vary widely across countries and have markedly evolved over the past two decades. The prognosis of very preterm infants has changed accordingly, raising new questions and requiring new assessments. We therefore set up the EPIPAGE-2 cohort, a new longitudinal study of preterm infants, with the following objectives: to provide actualized estimates of short- and long-...


Maternal education and cognitive development in 15 European very-preterm birth ...

Sentenac, M; Benhammou, V; Aden, U; Ancel, PY; Bakker, LA; Bakoy, H; Barros, H; Baumann, N; Bilsteen, JF; Boerch, K; Croci, I; Cuttini, M; Draper, E

Background Studies are sparse and inconclusive about the association between maternal education and cognitive development among children born very preterm (VPT). Although this association is well established in the general population, questions remain about its magnitude among children born VPT whose risks of medical and developmental complications are high. We investigated the association of maternal education...


Early extubation is not associated with severe intraventricular hemorrhage in p...

Chevallier, M; Ancel, PY; Torchin, H; Marchand-Martin, L; Lorthe, E; Truffert, P; Jarreau, PH; Roze, JC; Pierrat, V; Marret, S; Baud, O; Benhammou, V

Objective To determine whether there is an association between severe intraventricular hemorrhage and early extubation in preterm infants born before 29 weeks of gestational age and intubated at birth. Methods This study included 1587 preterm infants from a nationwide French population cohort (EPIPAGE-2). Secondary data on intubated preterm infants were analyzed. After gestational age and propensity score match...


Preterm premature rupture of membranes at 22-25 weeks' gestation: perinatal and...

Lorthe, E; Torchin, H; Delorme, P; Ancel, PY; Marchand-Martin, L; Foix-L'Helias, L; Benhammou, V; Gire, C; d'Ercole, C; Winer, N; Sentilhes, L

BACKGROUND: Most clinical guidelines state that with early preterm premature rupture of membranes, obstetric and pediatric teams must share a realistic and individualized appraisal of neonatal outcomes with parents and consider their wishes for all decisions. However, we currently lack reliable and relevant data, according to gestational age at rupture of membranes, to adequately counsel parents during pregnanc...


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