40 documents found, page 1 of 4
Cleavage of the TrkB-FL receptor during epileptogenesis: insights from a kainic...
Ribeiro Rodrigues, Leonor; Fonseca-Gomes, João; Paulo, Sara L; Viais, Ricardo; Ribeiro, Filipa; Miranda-Lourenço, Catarina; Mouro, FranciscoBrain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation, and plasticity. In epilepsy, BDNF exhibits a dual role, exerting both antiepileptic and pro-epileptic effects. The cleavage of its main receptor, full-length tropomyosin-related kinase B (TrkB-FL), was suggested to occur in status epilepticus (SE) in vitro. Moreover, under excitotoxic conditions, TrkB-FL was found to b...
Epilepsy Secondary to Occipital Cobblestone Malformation in an Adult Patient wi...
Schön, Miguel; Bentes, Carla; Morgado, Carlos; Oliveira Santos, MiguelN/a.; N/a.
Selective modulation of epileptic tissue by an adenosine A3 receptor‐activating...
Ghosh, Anwesha; Ribeiro Rodrigues, Leonor; Ruffolo, Gabriele; Alfano, Veronica; Domingos, Cátia; Rei, Nádia; Tosh, Dilip K.; Rombo, Diogo M.Background and purpose: Adenosine, through the A1 receptor (A1R), is an endogenous anticonvulsant. The development of adenosine receptor agonists as antiseizure medications has been hampered by their cardiac side effects. A moderately A1R-selective agonist, MRS5474, has been reported to suppress seizures without considerable cardiac action. Hypothesizing that this drug could act through other than A1R and/or th...
Acute Symptomatic Seizures in Patients with Recurrent Ischemic Stroke: A Multic...
Leal Rato, Miguel; Schön, Miguel; Zafra, Maria Paula; Aguiar de Sousa, Diana; Pinho E Melo, Teresa; Franco, Ana Catarina; Peralta, Ana RitaObjective: Epileptic seizures occur frequently after stroke due to changes in brain function and structure, and up to around 10% of stroke patients experience stroke recurrence in the first year. We aimed to establish the risk of acute symptomatic seizures in patients with recurrent stroke. Methods: Retrospective cohort study including consecutive admissions to a Stroke Unit due to acute ischemic stroke, during...
PO 75 - EPIDURAL CATHETER: SMALL SIZE, BIG TROUBLE
de Oliveira, Rita; Roberto C. Ferreira, Paulo; Bentes, Carlax
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistan...
Peltola, Jukka; Colon, Albert J.; Pimentel, José; Coenen, Volker A.; Gil-Nagel, Antonio; Gonçalves Ferreira, António; Lehtimäki, Kai; Ryvlin, PhilippeBackground and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therap...
Histopathological characterization of cerebral small vessel disease in epilepsy...
Coelho, Pedro; Madureira, João; Franco, Ana Catarina; Peralta, Ana; Bentes, Carla; Rainha Campos, Alexandre; Anink, Jasper; Aronica, EleonoraBackground: Cerebrovascular disease (CVD) is a major contributor to epilepsy; however, patients with epilepsy also have a significantly increased risk of stroke. The way in which epilepsy contributes to the increased risk of stroke is still uncertain and is ill-characterized in neuropathological studies. A neuropathological characterization of cerebral small vessel disease (cSVD) in patients with chronic epilep...
A novel approach to automatic seizure detection using computer vision and indep...
Garção, Vicente; Abreu, Mariana; Peralta, Ana; Bentes, Carla; Fred, Ana; Silva, HugoObjective: Epilepsy is a neurological disease that affects ~50 million people worldwide, 30% of which have refractory epilepsy and recurring seizures, which may contribute to higher anxiety levels and poorer quality of life. Seizure detection may contribute to addressing some of the challenges associated with this condition, by providing information to health professionals regarding seizure frequency, type, and...
Sleep and awakening quality during COVID-19 confinement : complexity and releva...
Paiva, Teresa; Reis, Cátia; Feliciano, Amélia; Canas Simião, Hugo; Machado, Maria Augusta; Gaspar, Tania; Tomé, Gina; Branquinho, Cátia Sofia dos SantosObjective: The aim of this study was to evaluate sleep and awakening quality (SQ and AQ) during COVID-19 in a large and diversified population in order to identify significant associations and risks in terms of demography, health and health-related behaviors, sleep variables, mental health, and attitudes. Methods/results: Online surveys were used for data collection, received from 5479 individuals from the gene...
Sighs during sleep in multiple system atrophy
Parreira, Sara; Antunes, Francisco; Coelho, Miguel; Bentes, Carla; Peralta, AnaSighs are physiological phenomena and may occasionally occur during sleep in healthy young adults. Although inspiratory sighs are considered a diagnostic red flag for the parkinsonian form of multiple system atrophy (MSA), its frequency and characteristics are unclear. We aimed to define sigh frequency during sleep recordings in patients with MSA compared to Parkinson's disease (PD) patients, as well as evaluat...