7 documents found, page 1 of 1
Gene expression evaluation of antioxidant enzymes in patients with hepatocellul...
Alves,Andressa de Freitas; Moura,Ana Carolina de; Andreolla,Huander Felipe; Veiga,Ana Beatriz Gorini da; Fiegenbaum,Marilu; Giovenardi,MárciaAbstract Any condition leading to chronic liver disease is a potential oncogenic agent for hepatocellular carcinoma (HCC). Alterations in the expression of antioxidant enzymes could alter the redox balance. Our aim was to evaluate the expression of the genes GPX1, GPX4, SEP15, SELENOP, SOD1, SOD2, GSR, CAT, and NFE2L2 in patients with HCC. Differential gene expression analysis was performed using RNA-Seq data f...
Blood groups in Native Americans: a look beyond ABO and Rh
Rodrigues,Mirelen Moura de Oliveira; Höher,Gabriela; Waskow,Gabriela; Hutz,Mara Helena; Lindenau,Juliana Dal-Ri; Petzl-Erler,Maria LuizaAbstract The study presents comparisons between blood group frequencies beyond ABO and Rh blood systems in Native American populations and previously published data from Brazilian blood donors. The frequencies of Diego (c.2561C>T, rs2285644), Kell (c.578C>T, rs8176058), Duffy (c.125A>G, rs12075, c.1−67T>C, rs2814778) and Kidd (c.838A>G, rs1058396) variants in Kaingang (n=72) and Guarani (n=234) populations from...
Genetic variability of blood groups in southern Brazil
Waskow,Gabriela; Rodrigues,Mirelen Moura de Oliveira; Höher,Gabriela; Onsten,Tor; Lindenau,Juliana Dal-Ri; Fiegenbaum,Marilu; Almeida,SilvanaAbstract We evaluated genetic variability among the blood groups Kell (c.578C > T and c.1790T > C), Kidd (c.838A > G), Duffy (c.125A > G, c.265C > T and c.1-67T > C), Diego (c.2561C > T), MNS (c.143T > C) and Rh (c.676G > C) in Rio Grande do Sul in southern Brazil. Genetic profiling from 382 volunteer blood donors was performed through allelic discrimination assays using a hydrolysis probe (TaqMan®) with a real...
Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with foo...
Feistauer,Vanessa; Vitolo,Márcia R.; Campagnolo,Paula D.B.; Mattevi,Vanessa S.; Almeida,SilvanaAbstract The reward sensation after food intake may be different between individuals and variants in genes related to the dopaminergic system may indicate a different response in people exposed to the same environmental factors. This study investigated the association of TaqIA (rs1800497) and -141C InsDel (rs1799732) variants in DRD2/ANKK1 gene with food intake and adiposity parameters in a cohort of children. ...
Evaluation of the association between the TAS1R2 and TAS1R3 variants and food i...
Melo,Silvia V.; Agnes,Grasiela; Vitolo,Márcia R.; Mattevi,Vanessa S.; Campagnolo,Paula D.B.; Almeida,SilvanaAbstract Taste perception plays a key role in determining individual food preferences and dietary habits and may influence nutritional status. This study aimed to investigate the association of TAS1R2 (Ile191Val - rs35874116) and TAS1R3 (-1266 C/T - rs35744813) variants with food intake and nutritional status in children followed from birth until 7.7 years old. The nutritional status and food intake data of 312...
Evaluation of Sexual Dimorphism in the Efficacy and Safety of Simvastatin/Atorv...
Smiderle,Lisiane; Lima,Luciana O.; Hutz,Mara Helena; Sand,Cézar Roberto Van der; Van der Sand,Luiz Carlos; Ferreira,Maria Elvira WagnerBackground: Dyslipidemia is the primary risk factor for cardiovascular disease, and statins have been effective in controlling lipid levels. Sex differences in the pharmacokinetics and pharmacodynamics of statins contribute to interindividual variations in drug efficacy and toxicity. Objective: To evaluate the presence of sexual dimorphism in the efficacy and safety of simvastatin/atorvastatin treatment. Method...
Transcriptional expression study in the central nervous system of rats: what ge...
Moura,Ana Carolina de; Lazzari,Virgínia Meneghini; Agnes,Grasiela; Almeida,Silvana; Giovenardi,Márcia; Veiga,Ana Beatriz Gorini daObjective A growing number of published articles report the expression of specific genes with different behavior patterns in rats. The levels of messenger ribonucleic acid transcripts are usually analyzed by reverse transcription followed by polymerase chain reaction and quantified after normalization with an internal control or reference gene (housekeeping gene). Nevertheless, housekeeping genes exhibit differ...