7 documents found, page 1 of 1
A robust phylogenomic time tree for biotechnologically and medically important ...
Rokas, Antonis
Characterizing the pathogenic, genomic, and chemical traits of Aspergillus fisc...
Rokas, Antonis
The Aspergillus fumigatus Mismatch Repair MSH2 Homolog Is Important for Virulen...
Dos Reis, Thaila Fernanda; Silva, Lilian Pereira; de Castro, Patrícia Alves; do Carmo, Rafaela Andrade; Marini, Marjorie MendesThe genetic stability of every living organism depends on accurate DNA replication and repair systems. Here, we investigated the Aspergillus fumigatusMSH2 mismatch repair (MMR) gene MshA and how it impacts virulence and the evolution of azole resistance. We examined mshA gene variation in 62 environmental and clinical A. fumigatus strains. We have observed 12 strains with variants (18.2%), and 8 strains among t...
Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic...
Gonçalves, Carla; Wisecaver, Jennifer H.; Kominek, Jacek; Oom, Madalena Salema; Leandro, Maria José; Shen, Xing-Xing; Opulente, Dana A.; Zhou, XiaofanFructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic...
Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic...
Gonçalves, Carla; Wisecaver, Jennifer H.; Kominek, Jacek; Oom, Madalena Salema; Leandro, Maria José; Shen, Xing-Xing; Opulente, Dana A.; Zhou, XiaofanABSTRACT: Fructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical a...
Drivers of genetic diversity in secondary metabolic gene clusters within a fung...
Rokas, Antonis
Drivers of genetic diversity in secondary metabolic gene clusters within a fung...
Lind, Abigail L.; Wisecaver, Jennifer H.; Lameiras, Catarina; Wiemann, Philipp; Palmer, Jonathan M.; Keller, Nancy P.Filamentous fungi produce a diverse array of secondary metabolites (SMs) critical for defense, virulence, and communication. The metabolic pathways that produce SMs are found in contiguous gene clusters in fungal genomes, an atypical arrangement for metabolic pathways in other eukaryotes. Comparative studies of filamentous fungal species have shown that SM gene clusters are often either highly divergent or uniq...