7 documents found, page 1 of 1
Characterization of novel double-reporter strains of Mycobacterium abscessus fo...
Bento, CM; Calster, K; Piller, T; Oliveira, GS; Vooght, L; Cappoen, D; Cos, P; Gomes, MS; Silva, TMycobacterium abscessus (Mab) is an emerging pathogen that poses a severe health threat, especially in people with cystic fibrosis and other chronic lung diseases. Available drugs are largely ineffective due to an exquisite intrinsic resistance, making Mab infections only comparable to multidrug-resistant tuberculosis. Current treatment is based on lengthy multidrug therapy, complicated by poor outcomes and hig...
Assay Development for High-Throughput Drug Screening Against Mycobacteria
Oliveira, GS; Bento, CM; Pombinho, A; Reis, R; Calster, K; Vooght, L; Maia, AF; Cos, P; Gomes, MS; Silva, TMycobacterium abscessus (Mab) infections are challenging to treat due to high intrinsic drug resistance, comparable to multidrug-resistant tuberculosis. Treatments are extremely ineffective and based on a multi-drug regimen, resulting in low patient compliance. Consequently, the scientific community is urged to identify new and effective drugs to treat these infections. One of the strategies employed to this en...
Improving the Antimycobacterial Drug Clofazimine through Formation of Organic S...
Bento, CM; Silva, AT; Mansano, B; Aguiar, L; Teixeira, C; Gomes, MS; Gomes, P; Silva, T; Ferraz, RThis work reports the synthesis, structural and thermal analysis, and in vitro evaluation of the antimicrobial activity of two new organic salts (OSs) derived from the antimycobacterial drug clofazimine and the fluoroquinolones ofloxacin or norfloxacin. Organic salts derived from active pharmaceutical ingredients (API-OSs), as those herein disclosed, hold promise as cost-effective formulations with improved fea...
Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adul...
Moreira, AC; Teles, MJ; Silva, T; Bento, CM; Alves, IS; Pereira, L; Guimarães, JT; Porto, G; Oliveira, P; Gomes, MSLarge variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients’ outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, from September to November 2020. One hundred and twenty-seven tested positive for SARS-CoV-2 and 176 tested negative....
Evolution of antibacterial drug screening methods: Current prospects for mycoba...
Bento, CM; Gomes, MS; Silva, TThe increasing resistance of infectious agents to available drugs urges the continuous and rapid development of new and more efficient treatment options. This process, in turn, requires accurate and high-throughput techniques for antimicrobials’ testing. Conventional methods of drug susceptibility testing (DST) are reliable and standardized by competent entities and have been thoroughly applied to a wide range ...
Looking beyond typical treatments for atypical mycobacteria
Bento, CM; Gomes, MS; Silva, TThe genus Mycobacterium comprises not only the deadliest of bacterial pathogens, Mycobacterium tuberculosis, but several other pathogenic species, including M. avium and M. abscessus. The incidence of infections caused by atypical or nontuberculous mycobacteria (NTM) has been steadily increasing, and is associated with a panoply of diseases, including pulmonary, soft-tissue, or disseminated infections. The trea...
Cinnamic acid conjugates in the rescuing and repurposing of classical antimalar...
Silva, AT; Bento, CM; Pena, AC; Figueiredo, LM; Prudêncio, C; Aguiar, L; Silva, T; Ferraz, R; Gomes, MS; Teixeira, C; Gomes, PCinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadil...