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Plant-derived bioactives and oxidative stress-related disorders: A key trend to...

Salehi, B; Azzini, E; Zucca, P; Varoni, EM; Kumar, NVA; Dini, L; Panzarini, E; Rajkovic, J; Fokou, PVT; Peluso, I; Mishra, AP; Nigam, M; Rayess, YE

Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hu...


Symphytum species: A comprehensive review on chemical composition, food applica...

Salehi, B; Sharopov, F; Tumer, TB; Ozleyen, A; Rodríguez-Pérez, C; Ezzat, SM; Azzini, E; Hosseinabadi, T; Butnariu, M; Sarac, I; Bostan, C; Acharya, K

Symphytum species belongs to the Boraginaceae family and have been used for centuries for bone breakages, sprains and rheumatism, liver problems, gastritis, ulcers, skin problems, joint pain and contusions, wounds, gout, hematomas and thrombophlebitis. Considering the innumerable potentialities of the Symphytum species and their widespread use in the world, it is extremely important to provide data compiling th...


Apium plants: Beyond simple food and phytopharmacological applications

Salehi, B; Venditti, A; Frezza, C; Yücetepe, A; Altuntas, Ü; Uluata, S; Butnariu, M; Sarac, I; Shaheen, S; Petropoulos, SA; Matthews, KR; Kiliç, CS

Apium plants belong to the Apiaceae family and are included among plants that have been in use in traditional medicine for thousands of years worldwide, including in the Mediterranean, as well as the tropical and subtropical regions of Asia and Africa. Some highlighted medical benefits include prevention of coronary and vascular diseases. Their phytochemical constituents consist of bergapten, flavonoids, glycos...


Kaempferol: A Key Emphasis to Its Anticancer Potential

Imran, M; Salehi, B; Sharifi Rad, J; Gondal, TA; Saeed, F; Imran, A; Shahbaz, M; Fokou, PVT; Arshad, MU; Khan, H; Susana Guerreiro; Martins, N

A marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective effect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, c...


Phytochemicals in prostate cancer: From bioactive molecules to upcoming therape...

Salehi, B; Fokou, PVT; Yamthe, LRT; Tali, BT; Adetunji, CO; Rahavian, A; Mudau, FN; Martorell, M; Setzer, WN; Rodrigues, CF; Martins, N; Cho, WC

Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constitue...


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