2 documents found, page 1 of 1
Lack of microsatellite instability in gastrointestinal stromal tumors
Campanella, Nathália C.; Scapulatempo-Neto, Cristovam; Abrahão-Machado, Lucas Faria; Oliveira, Antônio Talvane Torres; Berardinelli, Gustavo N.The microsatellite instability (MSI) phenotype may constitute an important biomarker for patient response to immunotherapy, particularly to anti-programmed death-1 inhibitors. MSI is a type of genomic instability caused by a defect in DNA mismatch repair (MMR) proteins, which is present mainly in colorectal cancer and its hereditary form, hereditary nonpolyposis colorectal cancer. Gastrointestinal stromal tumor...
Optimization of a pentaplex panel for MSI analysis without control DNA in a Bra...
Campanella, Nathália C.; Berardinelli, Gustavo N.; Scapulatempo-Neto, Cristovam; Viana, Danilo; Palmero, Edenir I.; Pereira, Rui; Reis, R. M.Microsatellite instability (MSI) testing has been advocated for all newly diagnosed colorectal cancer patients. One of the most common tests is composed by a pentaplex panel of mononucleotides markers (NR-27, NR-21, NR-24, BAT-25, and BAT-26), which allows the analysis of MSI in tumors without the need of reference DNA. For that, it is fundamental to establish a quasi-monomorphic variation range (QMVR) for each...