3 documents found, page 1 of 1
How chromosomal inversions reorient the evolutionary process
Berdan, Emma L.; Barton, Nicholas H.; Butlin, Roger; Charlesworth, Brian; Faria, Rui; De mendonça fragata almeida, Inês; Gilbert, Kimberly J.; Jay, PaulInversions are structural mutations that reverse the sequence of a chromosome segment and reduce the effective rate of recombination in the heterozygous state. They play a major role in adaptation, as well as in other evolutionary processes such as speciation. Although inversions have been studied since the 1920s, they remain difficult to investigate because the reduced recombination conferred by them strengthe...
Mutation accumulation opposes polymorphism: supergenes and the curious case of ...
Berdan, Emma L.; Blanckaert, Alexandre; Butlin, Roger K.; Flatt, Thomas; Slotte, Tanja; Wielstra, BenSupergenes offer spectacular examples of long-term balancing selection in nature, but their origin and maintenance remain a mystery. Reduced recombination between arrangements, a critical aspect of many supergenes, protects adaptive multi-trait phenotypes but can lead to mutation accumulation. Mutation accumulation can stabilize the system through the emergence of associative overdominance (AOD), destabilize th...
Unboxing mutations: Connecting mutation types with evolutionary consequences
Berdan, Emma L.; Blanckaert, Alexandre; Slotte, Tanja; Suh, Alexander; Westram, Anja M.; De mendonça fragata almeida, InêsA key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types (e.g., SNPs, translocations and inversions). To do this we must simultaneously consider different mutation types in an evolutionary framework. Here, we propose a research framework that directly utilizes the most important characteristics of mutations, ...