10 documents found, page 1 of 1
Genotoxicity of Three Micro/Nanocelluloses with Different Physicochemical Chara...
Ventura, Célia; Marques, Catarina; Cadete, João; Vilar, Madalena; Pedrosa, Jorge F. S.; Pinto, Fátima; Fernandes, Susete NogueiraBackground: Nanocellulose is an innovative engineered nanomaterial with an enormous potential for use in a wide array of industrial and biomedical applications and with fast growing economic value. The expanding production of nanocellulose is leading to an increased human exposure, raising concerns about their potential health effects. This study was aimed at assessing the potential toxic and genotoxic effects ...
Genotoxicity of Three Micro/Nanocelluloses with Different Physicochemical Chara...
Ventura, Célia; Marques, Catarina; Cadete, João; Vilar, Madalena; Pedrosa, Jorge F.S.; Pinto, Fátima; Fernandes, Susete Nogueira; da Rosa, Rafaela RauppBackground: Nanocellulose is an innovative engineered nanomaterial with an enormous potential for use in a wide array of industrial and biomedical applications and with fast growing economic value. The expanding production of nanocellulose is leading to an increased human exposure, raising concerns about their potential health effects. This study was aimed at assessing the potential toxic and genotoxic effects ...
Cyto-genotoxic effects of distinct micro/nanocelluloses in human osteoblastic a...
Ventura, Célia; Marques, Catarina; Cadete, João; Vilar, Madalena; Pedrosa, J.F.S.; Pinto, P.; Rosa, R.R.; Fernandes, S.N.; Godinho, M.H.The unique characteristics of micro/nanocelluloses (MNCs) have been boosting their use in a wide variety of industrial and biomedical applications. With the expected decrease of their production cost, it is likely to observe an even faster growing adoption of these materials in the coming years. With the increasing use of MNCs comes an increased likelihood of human exposure to these materials, raising concerns ...
Toxicidade da nanocelulose em modelos in vitro: um contributo para a avaliação ...
Ventura, Célia; Pinto, Fátima; Marques, Catarina; Cadete, João; Vilar, Madalena; Lourenço, Ana Filipa; Pedrosa, Jorge F. S.; Fernandes, Susete N.As nanoceluloses são nanomateriais inovadores com potencial para uma vasta gama de aplicações industriais e biomédicas. No entanto, a expansão da sua produção tem vindo a suscitar preocupações quanto aos possíveis efeitos, a longo prazo, na saúde humana. Este estudo teve como objetivo avaliar a segurança de algumas nanoceluloses produzidas a partir de matéria-prima nacional, através da caracterização da sua pot...
The use of the in vitro micronucleus assay on the genotoxicity assessment of ce...
Ventura, Célia; Teixeira, Sara; Marques, Catarina; Vilar, Madalena; Pinto, Fátima; Lourenço, A.F.; Sousa Mendes, A.; Ferreira, Paulo J.T.With the expansion of innovative cellulose nanofibrils (CNF) applications, either for industrial (e.g., paper industry) or biomedical purposes (e.g., tissue regeneration and dentistry), human exposure has been increasing, raising concerns about their potential health outcomes . Being persistent high aspect-ratio nano-objects, CNFs effects may resemble those of some multi-walled carbon nanotubes, e.g., the MWCNT...
Study on cellulose nanofibrils biological effects in different cellular models
Pinto, Fátima; Ventura, Célia; Teixeira, Sara; Vilar, Madalena; Lourenço, Ana Filipa; Ferreira, Paulo J.T.; Louro, Henriqueta; Silva, Maria JoãoCellulose nanofibrils (CNFs), is an innovative environmental friendly material that has been incorporated into several types of materials, in both pure and composite forms and holds great promise in different fields of application. This leads to a rising level of human exposure and draws considerable concerns regarding its potential toxicity in humans, which are specially motivated by the physicochemical resemb...
Safety assessment of nanofibrillated cellulose to human health using cellular m...
Ventura, Célia; Lourenço, Ana Filipa; Vilar, Madalena; Teixeira, Sara; Ferreira, Paulo J.T.; Silva, Maria JoãoNanomaterial - A natural, incidental or manufactured material containing particles, in an unbound state or as an aggregate or as an agglomerate and where, for 50% or more of the particles in the number size distribution, one or more external dimensions is in the size range 1 nm - 100 nm. In specific cases and where warranted by concerns for the environment, health, safety or competitiveness the number size dist...
Are cellulose nanofibrils safe for biomedical applications?
Vilar, Madalena; Lourenço, Ana Filipa; Ventura, Célia; Louro, Henriqueta; Ferreira, Paulo; Félix, Sérgio; Silva, Maria JoãoNanomedicine is based on the application of nanotechnologies into the medical field to advance and improve diagnostics, prevention and treatment of human disease. While its expansion has been enormous in the last years, its progress must go hand in hand with nanosafety, i.e., with the safety evaluation of nanomaterials in an early phase of its development or application into a product. Cellulose appears as a na...
Importance of cytology in the identification of villoglandular adenocarcinoma
Correia, Ana; Vilar, Madalena; Teixeira, CidáliaEndocervical villoglandular adenocarcinoma is a rare subtype of cervical adenocarcinoma. It arises mainly in young and reproductive age women and it has a lower incidence and better prognosis compared to cervical adenocarcinoma. The present case study refers to a conventional cytology performed on a 48-year-old woman within a screening program carried out at a health center of the Local Health Unit of Matosinho...
Importância da citologia na identificação do adenocarcinoma viloglandular
Correia, Ana; Vilar, Madalena; Teixeira, CidáliaO adenocarcinoma viloglandular do endocolo é um subtipo raro de adenocarcinoma cervical. Surge maioritariamente em mulheres jovens e em idade reprodutiva e apresenta menor incidência e melhor prognóstico quando comparado com o adenocarcinoma cervical. O presente caso de estudo refere-se a uma citologia convencional realizada a uma mulher de 48 anos no âmbito do programa de rastreio efetuado num centro de saúde ...