7 documents found, page 1 of 1
Ferritin heavy chain supports stability and function of the regulatory T cell l...
Wu, Qian; Carlos, Ana Rita; Braza, Faouzi; Bergman, Marie-Louise; Kitoko, Jamil Z; Bastos-Amador, Patricia; Cuadrado, Eloy; Martins, RuiRegulatory T (TREG) cells develop via a program orchestrated by the transcription factor forkhead box protein P3 (FOXP3). Maintenance of the TREG cell lineage relies on sustained FOXP3 transcription via a mechanism involving demethylation of cytosine-phosphate-guanine (CpG)-rich elements at conserved non-coding sequences (CNS) in the FOXP3 locus. This cytosine demethylation is catalyzed by the ten–eleven transl...
Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty...
Faro-Viana, João; Bergman, Marie-Louise; Gonçalves, Lígia A.; Duarte, Nadia; Coutinho, Teresa P.; Borges, Patricia C.; Diwo, Christian; Castro, RuteABSTRACT: While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at the population scale remains unclear. Here, in a prospective, longitudinal, cohort-study, including 1245 hospital care workers and 146 nursing home residents scheduled for BNT162b2 vaccination, together covering adult ages from 19 to 99 years, w...
The multifaceted Foxp3fgfp allele enhances spontaneous and therapeutic immune s...
Almeida-Santos, Jose; Bergman, Marie-Louise; Jocelyne, Demengeot; Correia, Vasco; Caramalho, Iris; Cabral, InesIt is well established that therapeutic impairment of Foxp3+ Treg in mice and humans favors immune rejection of solid tumors. Less explored is the impact Foxp3 allelic variants may have on tumor incidence, progression and therapy. In this work, we tested and demonstrate that the Foxp3fgfp reporter allele, found previously to either enhance or reduce Treg function in specific autoimmunity settings, confers incre...
Tolerogenic insulin peptide therapy precipitates type 1 diabetes
Bergman, Marie-Louise; Lopes-Carvalho, Thiago; Martins, Ana-Catarina; Grieco, Fabio A.; Eizirik, Décio L.; Demengeot, JocelyneDaniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened ...
Tolerogenic insulin peptide therapy precipitates type 1 diabetes
Bergman, Marie-Louise; Lopes-Carvalho, Thiago; Martins, Ana-Catarina; Grieco, Fabio A.; Eizirik, Décio L.; Demengeot, JocelyneDaniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened ...
Control of Disease Tolerance to Malaria by Nitric Oxide and Carbon Monoxide
Jeney, Viktória; Ramos, Susana; Bergman, Marie-Louise; Bechmann, Ingo; Tischer, Jasmin; Ferreira, Ana; Oliveira-Marques, Virginia; Janse, Chris J.Nitric oxide (NO) and carbon monoxide (CO) are gasotransmitters that suppress the development of severe forms of malaria associated with Plasmodium infection. Here, we addressed the mechanism underlying their protective effect against experimental cerebral malaria (ECM), a severe form of malaria that develops in Plasmodium-infected mice, which resembles, in many aspects, human cerebral malaria (CM). NO suppress...
Recent thymic emigrants are the preferential precursors of regulatory T cells d...
Paiva, Ricardo S.; Lino, Andreia C.; Bergman, Marie-Louise; Caramalho, Íris; Sousa, Ana E.; Zelenay, Santiago; Demengeot, JocelyneMost Forkhead box P3(+) (Foxp3(+)) CD4 regulatory T cell (Treg) precursors are newly formed thymocytes that acquire Foxp3 expression on antigen encounter in the thymus. Differentiation of Treg, however, can also occur in the periphery. What limits this second layer of self- and nonself-reactive Treg production in physiological conditions remains to be understood. In this work, we tested the hypothesis that, sim...