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MiR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 a...
Fuentes-Mattei, E; Bayraktar, R; Manshouri, T; Silva, AM; Ivan, C; Gulei, D; Fabris, L; Amaral, NS; Mur, P; Perez, C; Torres-Claudio, E; Dragomir, MPMyelofibrosis (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines and genetic alterations, such as JAKV617F mutation) have been implicated in the etiology of MF, but the molecular mechanism causing resistance to JAK2V617F inhibitor therapy remains unknown. Among MF patients who...
Date: 2020
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Origin: Repositório Aberto da Universidade do Porto