4 documents found, page 1 of 1
Diagnostic utility of threshold tracking TMS paradigms in early amyotrophic lat...
Calma, Aicee Dawn; Pavey, Nathan; Santos Silva, Cláudia; van den Bos, Mehdi A.J.; Yiannikas, Con; Farrar, Michelle A.; Kiernan, Matthew CObjective: Threshold tracking transcranial magnetic stimulation (TMS) has exhibited utility as a diagnostic technique in Amyotrophic Lateral Sclerosis (ALS). Different threshold tracking paradigms have recently been proposed. The present study assessed the diagnostic utility of serial ascending and parallel threshold tracking TMS in ALS. Methods: Threshold tracking TMS was undertaken on 90 prospectively recruit...
Utility of cortical inhibitory and facilitatory neuronal circuits in amyotrophi...
Santos Silva, Cláudia; Pavey, Nathan; Calma, Aicee Dawn; Kiernan, Matthew C.; Menon, Parvathi; van den Bos, Mehdi; Vucic, SteveBackground: Cortical hyperexcitability is an early feature of amyotrophic lateral sclerosis (ALS), linked to dysfunction in inhibitory and facilitatory cortical circuits, measurable using paired-pulse transcranial magnetic stimulation (TMS). Short-interval intracortical inhibition (SICI) is a robust biomarker of inhibitory function and an ALS diagnostic marker. Short interval intracortical facilitation (SICF) s...
Novel approaches to diagnosis and management of hereditary transthyretin amyloi...
Carroll, Antonia; Dyck, P. James; Carvalho, Mamede; Kennerson, Marina; Reilly, Mary M.; Kiernan, Matthew C.; Vucic, SteveHereditary transthyretin amyloidosis (ATTRv) is a severe, adult-onset autosomal dominant inherited systemic disease predominantly affecting the peripheral and autonomic nervous system, heart, kidney and the eyes. ATTRv is caused by mutations of the transthyretin (TTR) gene, leading to extracellular deposition of amyloid fibrils in multiple organs including the peripheral nervous system. Typically, the neuropath...
Split-hand and split-limb phenomena in amyotrophic lateral sclerosis: pathophys...
Corcia, Philippe; Bede, Peter; Pradat, Pierre-François; Couratier, Philippe; Vucic, Steve; Carvalho, MamedeAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting the upper and lower motor neurons. A key clinical feature of ALS is the absence of accurate, early-stage diagnostic indicators. 'Split-hand syndrome' was first described in ALS at the end of the last century and a considerable body of literature suggests that the split-hand phenomenon may be an important clinical feature o...